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Peptide record

TPDB12478

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12478
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 pep-lab Peptipedia
standard
No
A 12-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, pep-lab, and Peptipedia, with an available 3D structural model.
Sequence
RLWKIGKVLKWI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C77H126N20O13
ANDCEQHMFPSTY
K
1539.97
11.73
4
0
7
+4
0.19
0.200
154.17
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
7.14
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
12 reviewed residue count
C77H126N20O13 sequence-only estimate (linear, free termini)
1539.97 sequence-only estimate (linear, free termini)
11.73 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.19 sequence-only estimate (linear, free termini)
0.200 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of an Antibacterial Dodecapeptide From Pig as a Potential Food Preservative and Its Antibacterial Mechanism. | Food Funct | 2020