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Peptide record

TPDB12473

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12473
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLLKHKLLVTLA
Physicochemical Analysis
C66H121N17O14
RNDCEQGIMFPSWY
L
1376.79
10.84
4
0
7
+3
1.17
0.783
195.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
5
L
3
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C66H121N17O14
1376.79
10.84
+3
1.17
0.783
Evidence Records 2 records
Evidence 1 Activity

Activity

<20% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
<20% Hemolysis | 400 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
HJH-1, a Broad-Spectrum Antimicrobial Activity and Low Cytotoxicity Antimicrobial Peptide. | Molecules | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
8 %
Hemolytic
Hemolytic_activity: [Ref.30110916] 8% hemolysis at 50 µg/ml , 12% hemolysis at 100 µg/ml , 16% hemolysis at 200 µg/ml , 17% hemolysis at 300 µg/ml , 18% hemolysis at 400 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2018 Aug 14 23(8). pii: E2026. doi: 10.3390/molecules23082026.