Back to search

Peptide record

TPDB12464

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12464
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GWWRRTVAKARK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C69H111N25O14
NDCEQHILMFPSY
R
1514.80
12.71
5
0
5
+5
3.76
-1.367
40.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
7.26
1
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 1
Chemical Descriptors
12 reviewed residue count
C69H111N25O14 sequence-only estimate (linear, free termini)
1514.80 sequence-only estimate (linear, free termini)
12.71 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
3.76 sequence-only estimate (linear, free termini)
-1.367 sequence-only estimate (linear, free termini)
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

C. glutamicum ATCC 13032

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
100 µM

Target

S.aureus ATCC 9144

Source & Reference

dbAMP

Other

Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal:
Evidence 3 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

(MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µM

Target

A. pullulans

Source & Reference

dbAMP

Other

(MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
1.6 µM

Target

C. glutamicum ATCC 13032

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC
Evidence 8 Activity

Activity

MIC
Antifungal
100 µM

Target

S.aureus ATCC 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal:
Evidence 9 Activity

Activity

MIC
Antifungal
6.3 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 1.6 uM), S.aureus ATCC 9144 (MIC 100 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
50 µM

Target

A. pullulans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 14 Activity

Activity

1% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
1% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019