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Peptide record

TPDB12457

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12457
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLLRHRLLVTLA
Physicochemical Analysis
C66H121N21O14
NDCEQGIMFPSWY
L
1432.82
12.41
4
0
7
+3
0.81
0.683
195.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
5
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 5 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C66H121N21O14
1432.82
12.41
+3
0.81
0.683
Evidence Records 4 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
100-200 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 100-200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Potential of novel antimicrobial peptide P3 from bovine erythrocytes and its analogs to disrupt bacterial membranes in vitro and display activity against drug-resistant bacteria in a mouse model. | Antimicrob Agents Chemother | 2015
Evidence 2 Activity

Activity

13% Killing
Toxicity
100 µg/mL
Cytotoxic
13% Killing | 100 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Potential of novel antimicrobial peptide P3 from bovine erythrocytes and its analogs to disrupt bacterial membranes in vitro and display activity against drug-resistant bacteria in a mouse model. | Antimicrob Agents Chemother | 2015
Evidence 3 Activity

Activity

16% Killing
Toxicity
200 µg/mL
Cytotoxic
16% Killing | 200 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Potential of novel antimicrobial peptide P3 from bovine erythrocytes and its analogs to disrupt bacterial membranes in vitro and display activity against drug-resistant bacteria in a mouse model. | Antimicrob Agents Chemother | 2015
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
2 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25753638] 2% hemolysis at 50 µg/ml , 2.5% hemolysis at 100 µg/ml , 2.5% hemolysis at 200 µg/ml , 3% hemolysis at 300 µg/ml , 4% hemolysis at 400 µg/ml against human red blood cells | Cytotoxicity: [Ref.25753638] The cell viability of HaCaT cell lines is 84% and 80% at peptide concentrations of 200 and 400 µg/ml. In Kunming mice, the LD50 of JH-1 is 94 mg/kg for i.p. injection, while the LD50 of PMB(served as a control) is 50 mg/kg. No mortality

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2015 May 59(5):2835-41. doi: 10.1128/AAC.04932-14.