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Peptide record

TPDB12446

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12446
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WRFRWRFRWRFR
Physicochemical Analysis
C96H131N33O13
ANDCEQGHILKMPSTYV
R
1955.31
13.10
6
0
6
+6
-4.08
-1.775
0.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
843.86
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
3
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 3 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
12
C96H131N33O13
1955.31
13.10
+6
-4.08
-1.775
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. | J Med Chem | 2019
Evidence 2 Activity

Activity

MHC
Toxicity
64 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31276398] MHC=64µM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs). | Cytotoxicity: [Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RFR is 106.2%, 97.6%, 99.8%, 101.7%, 100.9%, 101.6%, 78.1% and 45.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2019 Aug 8 62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00307.