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Peptide record

TPDB12442

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12442
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
IIKKIIKKIIKK
Physicochemical Analysis
C72H140N18O13
ARNDCEQGHLMFPSTWYV
IK
1466.02
11.21
6
0
6
+6
4.08
0.300
195.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
6
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 6 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C72H140N18O13
1466.02
11.21
+6
4.08
0.300
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
30 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against Gram-positive pathogens S. aureus (MIC 30 uM), B. subtilis (MIC 5 uM), Gram-negative pathogens E. coli BL21 or ESBL strain (MIC 20-30 u
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

B. subtilis

Source & Reference

NA

Other

Active against Gram-positive pathogens S. aureus (MIC 30 uM), B. subtilis (MIC 5 uM), Gram-negative pathogens E. coli BL21 or ESBL strain (MIC 20-30 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
20-30 µM

Target

Escherichia coli BL21 or ESBL strain

Source & Reference

NA

Other

positive pathogens S. aureus (MIC 30 uM), B. subtilis (MIC 5 uM), Gram-negative pathogens E. coli BL21 or ESBL strain (MIC 20-30 uM).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>1000 µM
Hemolytic Cytotoxic
50% Hemolysis | >1000 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
High Selective Performance of Designed Antibacterial and Anticancer Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2015
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>2000 µM
Hemolytic Cytotoxic
50% Hemolysis | >2000 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
How do terminal modifications of short designed IIKK peptide amphiphiles affect their antifungal activity and biocompatibility? | J Colloid Interface Sci | 2022
Evidence 6 Activity

Activity

IC50
Toxicity
>800 µM
Cytotoxic
IC50 | >800 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
How do terminal modifications of short designed IIKK peptide amphiphiles affect their antifungal activity and biocompatibility? | J Colloid Interface Sci | 2022
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
nterfaces. 2015 Aug 12 7(31):17346-57.