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Peptide record

TPDB12441

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12441
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
YLRLIRYMAKMI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C73H123N19O15S2
NDCEQGHFPSTWV
RILMY
1571.02
10.59
3
0
9
+3
0.79
0.558
138.33
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
2980
1.90
2
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
1
K
2
M
0
F
0
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 1 M: 2 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
12 reviewed residue count
C73H123N19O15S2 sequence-only estimate (linear, free termini)
1571.02 sequence-only estimate (linear, free termini)
10.59 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.79 sequence-only estimate (linear, free termini)
0.558 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 125 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations. | Nat Biomed Eng | 2021