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Peptide record

TPDB12420

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12420
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWLRWWTRWRLK
Physicochemical Analysis
C90H131N29O14
ANDCEQGHIMFPSYV
RW
1843.22
12.88
5
0
6
+5
-4.15
-1.550
65.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1193.57
1
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
1
K
0
M
0
F
0
P
0
S
1
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 4 Y: 0 V: 0
Chemical Descriptors
12
C90H131N29O14
1843.22
12.88
+5
-4.15
-1.550
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. | J Med Chem | 2019
Evidence 2 Activity

Activity

MHC
Toxicity
128 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31276398] MHC=128µM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs). | Cytotoxicity: [Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 4W is 95.3%, 88.3%, 89.7%, 97.9%, 91.2%, 77.6%, 32.8% and 0% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2019 Aug 8 62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00299.