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Peptide record

TPDB12392

Antibacterial Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB12392
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 11-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRRWRKRRWWW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C86H126N34O12
ANDCEQGHILMFPSTYV
R
1828.17
13.10
7
0
4
+7
7.80
-3.136
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
12.03
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
11 reviewed residue count
C86H126N34O12 sequence-only estimate (linear, free termini)
1828.17 sequence-only estimate (linear, free termini)
13.10 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
7.80 sequence-only estimate (linear, free termini)
-3.136 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

<=5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<=5% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 2 Activity

Activity

0% Killing
Toxicity
<128 µg/mL
Cytotoxic
0% Killing | <128 | µg/mL | target cell: Murine dendritic cells JAWS II

Target

Murine dendritic cells JAWS II

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 3 Activity

Activity

13% Killing
Toxicity
512 µg/mL
Cytotoxic
13% Killing | 512 | µg/mL | target cell: Murine dendritic cells JAWS II

Target

Murine dendritic cells JAWS II

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 4 Activity

Activity

0% Killing
Toxicity
64 µg/mL
Cytotoxic
0% Killing | 64 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018
Evidence 5 Activity

Activity

20% Killing
Toxicity
512 µg/mL
Cytotoxic
20% Killing | 512 | µg/mL | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria. | BMC Microbiol | 2018