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Peptide record

TPDB12385

Antibacterial Antifungal Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB12385
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
GFIVKRFKILV
Physicochemical Analysis
C66H110N16O12
ANDCEQHMPSTWY
IKFV
1319.70
11.64
3
0
7
+3
-0.50
1.282
159.09
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
1
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
11
C66H110N16O12
1319.70
11.64
+3
-0.50
1.282
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
97 µM

Target

B. subtilis 168 HT

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 97 uM), E.coli MG1655 (MIC >97 uM), and C.trachomatis D/UW-3/Cx (MIC90 >100 uM). Note that wheth
Evidence 2 Activity

Activity

MIC
Antibacterial
>97 µM

Target

E.coli MG1655

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 97 uM), E.coli MG1655 (MIC >97 uM), and C.trachomatis D/UW-3/Cx (MIC90 >100 uM). Note that whether this is a or part of the
Evidence 3 Activity

Activity

MIC
Antifungal
97 µM

Target

B. subtilis 168 HT

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 97 uM), E.coli MG1655 (MIC >97 uM), and C.trachomatis D/UW-3/Cx (MIC90 >100 uM). Note that wheth
Evidence 4 Activity

Activity

MIC
Antifungal
>97 µM

Target

E.coli MG1655

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 97 uM), E.coli MG1655 (MIC >97 uM), and C.trachomatis D/UW-3/Cx (MIC90 >100 uM). Note that whether this is a or part of the
Evidence 5 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens. | Eur J Med Chem | 2019