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Peptide record

TPDB12375

Antibacterial Anticancer Antifungal Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB12375
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
LRKVWRWLRRL
Physicochemical Analysis
C75H124N26O12
ANDCEQGHIMFPSTY
R
1581.98
12.88
5
0
6
+5
-1.08
-0.736
132.73
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
11000
695.33
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
1
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
11
C75H124N26O12
1581.98
12.88
+5
-1.08
-0.736
Evidence Records 3 records
Evidence 1 Activity

Activity

92% Killing
Toxicity
100 µM
Cytotoxic
92% Killing | 100 | µM | target cell: Human normal embryonic lung cells L132

Target

Human normal embryonic lung cells L132

Source & Reference

NA
DBAASP
Rationally designed antimicrobial peptides: Insight into the mechanism of eleven residue peptides against microbial infections. | Biochim Biophys Acta | 2020
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rationally designed antimicrobial peptides: Insight into the mechanism of eleven residue peptides against microbial infections. | Biochim Biophys Acta | 2020
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biophys Acta Biomembr. 2020 Apr 1 1862(4):183178.