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Peptide record

TPDB12341

Antibacterial Antifungal Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB12341
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 11-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FLKWALKWAAK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C70H104N16O12
RNDCEQGHIMPSTYV
AK
1361.70
10.84
3
0
8
+3
-0.57
0.209
98.18
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
8.08
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
3
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
11 reviewed residue count
C70H104N16O12 sequence-only estimate (linear, free termini)
1361.70 sequence-only estimate (linear, free termini)
10.84 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.57 sequence-only estimate (linear, free termini)
0.209 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
64.03 µM
Hemolytic Cytotoxic
50% Hemolysis | 64.03 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Enhanced Antimicrobial Activity of N-Terminal Derivatives of a Novel Brevinin-1 Peptide from The Skin Secretion of Odorrana schmackeri. | Toxins (Basel) | 2020
Evidence 2 Activity

Activity

30% Killing
Toxicity
0.1 µM
Cytotoxic
30% Killing | 0.1 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Enhanced Antimicrobial Activity of N-Terminal Derivatives of a Novel Brevinin-1 Peptide from The Skin Secretion of Odorrana schmackeri. | Toxins (Basel) | 2020
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis