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Peptide record

TPDB12328

Antibacterial Anticancer Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB12328
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 11-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KKLGLCLGLKK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C55H105N15O12S1
ARNDEQHIMFPSTWYV
LK
1200.59
10.55
4
0
4
+4
-0.06
0.118
141.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
4
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11 reviewed residue count
C55H105N15O12S1 sequence-only estimate (linear, free termini)
1200.59 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.06 sequence-only estimate (linear, free termini)
0.118 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short, symmetric-helical peptides have narrow-spectrum activity with low resistance potential and high selectivity. | Biomater Sci | 2019