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Peptide record

TPDB12319

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB12319
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 10-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
ALWKKLLKKA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C59H103N15O11
RNDCEQGHIMFPSTYV
K
1198.56
11.00
4
0
6
+4
0.15
-0.150
137.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
4.59
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
4
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
10 reviewed residue count
C59H103N15O11 sequence-only estimate (linear, free termini)
1198.56 sequence-only estimate (linear, free termini)
11.00 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.15 sequence-only estimate (linear, free termini)
-0.150 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
64-256 µM
Hemolytic Cytotoxic
5% Hemolysis | 64-256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients | Biomolecules | 2019