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Peptide record

TPDB12313

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB12313
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
FIIWPLRYRK
Physicochemical Analysis
C70H106N18O12
ANDCEQGHMSTV
RI
1391.73
11.39
3
0
6
+3
-2.04
-0.110
117.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
502.25
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
1
L
1
K
0
M
1
F
1
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
10
C70H106N18O12
1391.73
11.39
+3
-2.04
-0.110
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
180 µM
Hemolytic Cytotoxic
<5% Hemolysis | 180 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Somuncurins: Bioactive Peptides From the Skin of the Endangered Endemic Patagonian Frog Pleurodema somuncurense. | J Nat Prod | 2020
Evidence 2 Activity

Activity

8% Hemolysis
Toxicity
400 µM
Hemolytic Cytotoxic
8% Hemolysis | 400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Somuncurins: Bioactive Peptides From the Skin of the Endangered Endemic Patagonian Frog Pleurodema somuncurense. | J Nat Prod | 2020
Evidence 3 Activity

Activity

0% Cytotoxicity
Toxicity
100 µM
Cytotoxic
0% Cytotoxicity | 100 | µM | target cell: Human monocyte-derived macrophages

Target

Human monocyte-derived macrophages

Source & Reference

NA
DBAASP
Somuncurins: Bioactive Peptides From the Skin of the Endangered Endemic Patagonian Frog Pleurodema somuncurense. | J Nat Prod | 2020