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Peptide record

TPDB12306

Antibacterial Anticancer Antifungal Antiparasitic standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB12306
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF CAFPdb
standard
No
A 10-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RFPWWWPFLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C79H99N19O11
ANDCEQGHIKMSTYV
W
1490.78
12.40
2
0
6
+2
1.20
-0.550
39.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
11.07
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
2
F
2
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 2 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
10 reviewed residue count
C79H99N19O11 sequence-only estimate (linear, free termini)
1490.78 sequence-only estimate (linear, free termini)
12.40 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
1.20 sequence-only estimate (linear, free termini)
-0.550 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
500 µg/mL

Target

A.fumigatus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
monia, S.epidermidis, P.mirabilis, and Streptococcus group D. Poorly active against fungi A.fumigatus (MIC 500 ug/ml) and C.albicans (>1000 ug/ml).
Evidence 2 Activity

Activity

MIC
Antifungal
500 µg/mL

Target

A.fumigatus

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
monia, S.epidermidis, P.mirabilis, and Streptococcus group D. Poorly active against fungi A.fumigatus (MIC 500 ug/ml) and C.albicans (>1000 ug/ml).
Evidence 3 Activity

Activity

MIC
Antiparasitic
500 µg/mL

Target

A.fumigatus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
monia, S.epidermidis, P.mirabilis, and Streptococcus group D. Poorly active against fungi A.fumigatus (MIC 500 ug/ml) and C.albicans (>1000 ug/ml).