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Peptide record

TPDB12285

Antibacterial Anticancer Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB12285
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 10-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RWRWWWRWRA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C82H105N27O11
NDCEQGHILKMFPSTYV
W
1644.91
12.88
4
0
6
+4
4.62
-2.070
10.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
27500
16.72
0
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
10 reviewed residue count
C82H105N27O11 sequence-only estimate (linear, free termini)
1644.91 sequence-only estimate (linear, free termini)
12.88 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
4.62 sequence-only estimate (linear, free termini)
-2.070 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Therapeutic Potential of Trp-Rich Engineered Amphiphiles by Single Hydrophobic Amino Acid End-Tagging | ACS Appl Mater Interfaces | 2019
Evidence 2 Activity

Activity

15% Cytotoxicity
Toxicity
32 µM
Cytotoxic
15% Cytotoxicity | 32 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Therapeutic Potential of Trp-Rich Engineered Amphiphiles by Single Hydrophobic Amino Acid End-Tagging | ACS Appl Mater Interfaces | 2019
Evidence 3 Activity

Activity

10% Cytotoxicity
Toxicity
32 µM
Cytotoxic
10% Cytotoxicity | 32 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Therapeutic Potential of Trp-Rich Engineered Amphiphiles by Single Hydrophobic Amino Acid End-Tagging | ACS Appl Mater Interfaces | 2019
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
10% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Optimizing therapeutic efficacy of antifungal peptides via strategic terminal amino acid modification | J Adv Res | 2025