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Peptide record

TPDB12280

Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB12280
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
Sequence
KWWKLLRKKR
Physicochemical Analysis
C70H116N22O11
ANDCEQGHIMFPSTYV
K
1441.83
12.44
6
0
4
+6
0.76
-1.880
78.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
762.92
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C70H116N22O11
1441.83
12.44
+6
0.76
-1.880
Evidence Records 3 records
Evidence 1 Activity

Activity

24% Killing
Toxicity
100 µg/mL
Cytotoxic
24% Killing | 100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Novel formulation of antimicrobial peptides enhances antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). | Amino Acids | 2020
Evidence 2 Activity

Activity

<1% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
<1% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Novel formulation of antimicrobial peptides enhances antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA). | Amino Acids | 2020
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2020 Oct 52(10):1439-1458.