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Peptide record

TPDB12279

Antibacterial Anticancer Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB12279
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KKLRLKIAFK
Physicochemical Analysis
C60H109N17O11
NDCEQGHMPSTWYV
K
1244.63
11.80
5
0
5
+5
2.04
-0.340
127.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
4
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C60H109N17O11
1244.63
11.80
+5
2.04
-0.340
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus ATCC 12600 or ATCC 25923

Source & Reference

NA

Other

active against S. aureus ATCC 12600 or ATCC 25923 (MIC 32 uM) or greater, E. faecalis ATCC 19433 (MIC 4-8 uM), P. aeruginosa H1001 or PAO1 or PA14 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Enterococcus faecalis ATCC 19433

Source & Reference

NA

Other

active against S. aureus ATCC 12600 or ATCC 25923 (MIC 32 uM) or greater, E. faecalis ATCC 19433 (MIC 4-8 uM), P. aeruginosa H1001 or PAO1 or PA14 (MIC 32-40 uM), and E. coli ATCC 25922 or KpC+ 00181
Evidence 3 Activity

Activity

MIC
Antibacterial
32-40 µM

Target

Pseudomonas aeruginosa H1001 or PAO1 or PA14

Source & Reference

NA

Other

eus ATCC 12600 or ATCC 25923 (MIC 32 uM) or greater, E. faecalis ATCC 19433 (MIC 4-8 uM), P. aeruginosa H1001 or PAO1 or PA14 (MIC 32-40 uM), and E. coli ATCC 25922 or KpC+ 001812446 or BL21 (MIC 4-32 uM), K-pneumoniae (MIC>32 uM)
Evidence 4 Activity

Activity

<5% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
<5% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential. | ACS Infect Dis | 2019
Evidence 5 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential. | ACS Infect Dis | 2019
Evidence 6 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential. | ACS Infect Dis | 2019
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Infect Dis. 2019 Jul 12 5(7):1081-1086.