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Peptide record

TPDB12265

Antibacterial Antiviral Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB12265
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbAMP 3.0 DRAVP 2.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
ATCYCRTGR
Physicochemical Analysis
C40H67N15O13S2
NDEQHILKMFPSWV
RCT
1030.18
9.09
2
0
2
+2
0.32
-0.589
11.11
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1615
156.77
5
Residue Composition
number
1
A
2
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
9
C40H67N15O13S2
1030.18
9.09
+2
0.32
-0.589
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

A. baumannii 4-MRGN

Source & Reference

NA

Other

rhamnosus, L. salivarius, and S. solivarius salivarius. In addition, it is active against A. baumannii 4-MRGN (MIC 25 uM), K.pneumoniae 3-MRGN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

on, it is active against A. baumannii 4-MRGN (MIC 25 uM), K.pneumoniae 3-MRGN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747 (MIC 12.5 uM), and S. aureus USA300 (MIC 50 uM). Updated 7/2021 3/202
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

E. faecium 475747

Source & Reference

NA

Other

4-MRGN (MIC 25 uM), K.pneumoniae 3-MRGN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747 (MIC 12.5 uM), and S. aureus USA300 (MIC 50 uM). Updated 7/2021 3/2023
Evidence 4 Activity

Activity

MIC
Antibacterial
50 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

GN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747 (MIC 12.5 uM), and S. aureus USA300 (MIC 50 uM). Updated 7/2021 3/2023
Evidence 5 Activity

Activity

MIC
Antiviral
25 µM

Target

A. baumannii 4-MRGN

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
rhamnosus, L. salivarius, and S. solivarius salivarius. In addition, it is active against A. baumannii 4-MRGN (MIC 25 uM), K.pneumoniae 3-MRGN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747
Evidence 6 Activity

Activity

MIC
Antiviral
50 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

on, it is active against A. baumannii 4-MRGN (MIC 25 uM), K.pneumoniae 3-MRGN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747 (MIC 12.5 uM), and S. aureus USA300 (MIC 50 uM). Updated 7/2021 3/202
Evidence 7 Activity

Activity

MIC
Antiviral
12.5 µM

Target

E. faecium 475747

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

4-MRGN (MIC 25 uM), K.pneumoniae 3-MRGN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747 (MIC 12.5 uM), and S. aureus USA300 (MIC 50 uM). Updated 7/2021 3/2023
Evidence 8 Activity

Activity

MIC
Antiviral
50 µM

Target

Staphylococcus aureus USA300

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

GN (inactive), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecium 475747 (MIC 12.5 uM), and S. aureus USA300 (MIC 50 uM). Updated 7/2021 3/2023
Evidence 9 Activity

Activity

50% Cytotoxicity
Toxicity
>150 µM
Cytotoxic
50% Cytotoxicity | >150 | µM | target cell: Human retinal epithelial cells ARPE-19

Target

Human retinal epithelial cells ARPE-19

Source & Reference

NA
DBAASP
The Human ?-Defensin-Derived Peptide HD5(1-9) Inhibits Cellular Attachment and Entry of Human Cytomegalovirus | Antiviral Res | 2020