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Peptide record

TPDB12259

Antibacterial Anticancer Antifungal Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB12259
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 CAFPdb dbAMP
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
KRWWKWWRR
Physicochemical Analysis
C74H102N24O10
ANDCEQGHILMFPSTYV
W
1487.78
12.71
5
0
4
+5
-2.99
-2.767
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
22000
1478.71
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
9
C74H102N24O10
1487.78
12.71
+5
-2.99
-2.767
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.3-5.7 µM

Target

Pseudomonas aeruginosa PAO1 or WT or resistant strains

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
11 µM

Target

Enterobacter cloacae Strain C601

Source & Reference

dbAMP

Other

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.
Evidence 3 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli ESBL

Source & Reference

dbAMP

Other

osa PAO1 or WT or resistant strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis AT
Evidence 4 Activity

Activity

MIC
Antibacterial
22 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP

Other

nt strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis ATCC29212 (MIC 1.1-43 uM) ant
Evidence 5 Activity

Activity

MIC
Antibacterial
1.4-3 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP

Other

, E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis ATCC29212 (MIC 1.1-43 uM) anti-VRE 2 strains =>174 uM (AMP-resistant?).
Evidence 6 Activity

Activity

MIC
Antibacterial
1.1-43 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP

Other

SBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis ATCC29212 (MIC 1.1-43 uM) anti-VRE 2 strains =>174 uM (AMP-resistant?).
Evidence 7 Activity

Activity

MIC
Antifungal
0.3-5.7 µM

Target

Pseudomonas aeruginosa PAO1 or WT or resistant strains

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM),
Evidence 8 Activity

Activity

MIC
Antifungal
11 µM

Target

Enterobacter cloacae Strain C601

Source & Reference

dbAMP CAFPdb

Other

active against 6 P. aeruginosa PAO1 or WT or resistant strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.
Evidence 9 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli ESBL

Source & Reference

dbAMP CAFPdb

Other

osa PAO1 or WT or resistant strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis AT
Evidence 10 Activity

Activity

MIC
Antifungal
22 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP CAFPdb

Other

nt strains (MIC 0.3-5.7 uM), E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis ATCC29212 (MIC 1.1-43 uM) ant
Evidence 11 Activity

Activity

MIC
Antifungal
1.4-3 µM

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP CAFPdb

Other

, E. cloacae Strain C601 (MIC 11 uM), E. coli ESBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis ATCC29212 (MIC 1.1-43 uM) anti-VRE 2 strains =>174 uM (AMP-resistant?).
Evidence 12 Activity

Activity

MIC
Antifungal
1.1-43 µM

Target

Enterococcus faecalis ATCC29212

Source & Reference

dbAMP CAFPdb

Other

SBL (MIC 3 uM), K. pneumoniae (MIC 22 uM), S. aureus ATCC 25923 or MRSA (MIC 1.4-3 uM), 5 E. faecalis ATCC29212 (MIC 1.1-43 uM) anti-VRE 2 strains =>174 uM (AMP-resistant?).
Evidence 13 Activity

Activity

6% Hemolysis
Toxicity
188 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 188 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. | ACS Chem Biol | 2009