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Peptide record

TPDB12257

Antibacterial Antifungal Hemolysis Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB12257
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FFFFKKKKK
Physicochemical Analysis
C66H98N14O10
ARNDCEQGHILMPSTWYV
K
1247.59
11.12
5
0
4
+5
0.43
-0.922
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
4
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C66H98N14O10
1247.59
11.12
+5
0.43
-0.922
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
>150 µg/mL
Cytotoxic
50% Cell death | >150 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 2 Activity

Activity

50% Cell death
Toxicity
27.5 µg/mL
Cytotoxic
50% Cell death | 27.5 | µg/mL | target cell: Human Colon Epithelial Cells HCEC

Target

Human Colon Epithelial Cells HCEC

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>32 µg/mL
Cytotoxic
50% Cell death | >32 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>32 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis