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Peptide record

TPDB12252

Antibacterial Anticancer Antifungal Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB12252
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 9-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RWRFKWWKK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C72H101N21O10
ANDCEQGHILMPSTYV
KW
1420.73
12.43
5
0
4
+5
4.06
-2.289
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
11.61
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
3
K
0
M
1
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
9 reviewed residue count
C72H101N21O10 sequence-only estimate (linear, free termini)
1420.73 sequence-only estimate (linear, free termini)
12.43 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
4.06 sequence-only estimate (linear, free termini)
-2.289 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans. | Biochem Biophys Res Commun | 2020
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Rat myoblast L6 cells

Target

Rat myoblast L6 cells

Source & Reference

NA
DBAASP
A designed antifungal peptide with therapeutic potential for clinical drug-resistant Candida albicans. | Biochem Biophys Res Commun | 2020