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Peptide record

TPDB12251

Antibacterial Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB12251
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 9-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLLKWLLKL
Physicochemical Analysis
C59H103N13O10
ARNDCEQGHIMFPSTYV
L
1154.55
10.84
3
0
6
+3
-1.68
0.711
216.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
476.38
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
9
C59H103N13O10
1154.55
10.84
+3
-1.68
0.711
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ B. subtilis ATCC 6633 (MIC 12.5 ug/ml), S. aureus ATCC 6538p (MIC 3.1 ug/ml), S.epidermis ATCC 12228 (MIC 12.5 ug/ml), M. luteus
Evidence 2 Activity

Activity

MIC
Antibacterial
3.1 µg/mL

Target

Staphylococcus aureus ATCC 6538p

Source & Reference

dbAMP DRAMP

Other

active against Gram+ B. subtilis ATCC 6633 (MIC 12.5 ug/ml), S. aureus ATCC 6538p (MIC 3.1 ug/ml), S.epidermis ATCC 12228 (MIC 12.5 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), Gram- E. c
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

S.epidermis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

ainst Gram+ B. subtilis ATCC 6633 (MIC 12.5 ug/ml), S. aureus ATCC 6538p (MIC 3.1 ug/ml), S.epidermis ATCC 12228 (MIC 12.5 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysen
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

M. luteus ATCC 10240

Source & Reference

dbAMP DRAMP

Other

.5 ug/ml), S. aureus ATCC 6538p (MIC 3.1 ug/ml), S.epidermis ATCC 12228 (MIC 12.5 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 12.5 ug/ml), S.
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

/ml), S.epidermis ATCC 12228 (MIC 12.5 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 12.5 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K.
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

S. dysentariae ATCC 9752

Source & Reference

dbAMP DRAMP

Other

5 ug/ml), M. luteus ATCC 10240 (MIC 25 ug/ml), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 12.5 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

S. typhimorium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

l), Gram- E. coli ATCC 25922 (MIC 12.5 ug/ml), S. dysentariae ATCC 9752 (MIC 12.5 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 50 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
6.3 µg/mL

Target

Klebsiella pneumoniae ATCC 10031

Source & Reference

dbAMP DRAMP

Other

ml), S. dysentariae ATCC 9752 (MIC 12.5 ug/ml), S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 50 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

, S. typhimorium ATCC 14028 (MIC 25 ug/ml), K. pneumoniae ATCC 10031 (MIC 6.3 ug/ml), and P. aeruginosa ATCC 27853 (MIC 50 ug/ml).
Evidence 10 Activity

Activity

7% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface. | J Pept Sci | 2009