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Peptide record

TPDB12248

Antibacterial Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB12248
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 8-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RWYRRWYR
Physicochemical Analysis
C64H88N22O11
ANDCEQGHILKMFPSTV
R
1341.54
11.94
4
0
4
+4
-2.34
-2.800
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
13980
1042.08
2
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 2 V: 0
Chemical Descriptors
8
C64H88N22O11
1341.54
11.94
+4
-2.34
-2.800
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
393 µM
Cytotoxic
50% Cytotoxicity | 393 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018