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Peptide record

TPDB12236

Antibacterial Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB12236
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 8-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRRRWWWL
Physicochemical Analysis
C63H91N23O9
ANDCEQGHIKMFPSTYV
R
1314.56
12.88
4
0
4
+4
-2.87
-2.112
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
1255.17
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
8
C63H91N23O9
1314.56
12.88
+4
-2.87
-2.112
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Staphylococcus aureus M838-17

Source & Reference

NA

Other

active against S. aureus M838-17 (MIC 6.25 uM), P. aeruginosa E411-17 (MIC 12.5 uM), and K-pneumoniae E406-17 (MIC >50 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Pseudomonas aeruginosa E411-17

Source & Reference

NA

Other

active against S. aureus M838-17 (MIC 6.25 uM), P. aeruginosa E411-17 (MIC 12.5 uM), and K-pneumoniae E406-17 (MIC >50 uM).
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020