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Peptide record

TPDB12223

Antibacterial Anticancer Antifungal Antiparasitic standard
50 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12223
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 50-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ELCEKASKTWSGNCGNTGHCDNQCKSWEGAAHGACHVRNGKHMCFCYFNC
Physicochemical Analysis
C228H337N73O71S9
IP
C
5525.17
7.53
9
4
12
+1
9.09
-0.690
21.60
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
12990
235.11
20
Residue Composition
number
4
A
1
R
5
N
1
D
8
C
3
E
1
Q
6
G
4
H
0
I
1
L
4
K
1
M
2
F
0
P
3
S
2
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 5 D: 1 C: 8 E: 3 Q: 1 G: 6 H: 4 I: 0 L: 1 K: 4 M: 1 F: 2 P: 0 S: 3 T: 2 W: 2 Y: 1 V: 1
Chemical Descriptors
50
C228H337N73O71S9
5525.17
7.53
+1
9.09
-0.690
Evidence Records 21 records
Evidence 1 Activity

Activity

IC50
Antibacterial
12 µg/mL

Target

B. cinerea

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5
Evidence 2 Activity

Activity

IC50
Antibacterial
3 µg/mL

Target

C. sphaerospermum

Source & Reference

dbAMP DRAMP

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml
Evidence 3 Activity

Activity

IC50
Antibacterial
2.8-5 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP

Other

ide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), an
Evidence 4 Activity

Activity

IC50
Antibacterial
1.5 µg/mL

Target

L. maculans

Source & Reference

dbAMP DRAMP

Other

inerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml)
Evidence 5 Activity

Activity

IC50
Antibacterial
2 µg/mL

Target

P. digitatum

Source & Reference

dbAMP DRAMP

Other

aerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(
Evidence 6 Activity

Activity

IC50
Antibacterial
1 µg/mL

Target

S. tritici

Source & Reference

dbAMP DRAMP

Other

. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). It contains 4 S
Evidence 7 Activity

Activity

IC50
Antibacterial
4 µg/mL

Target

V. albo-atrum

Source & Reference

dbAMP DRAMP

Other

L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). It contains 4 S-S bonds. IC50= 50% inhibition of
Evidence 8 Activity

Activity

IC50
Antifungal
12 µg/mL

Target

B. cinerea

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5
Evidence 9 Activity

Activity

IC50
Antifungal
3 µg/mL

Target

C. sphaerospermum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml
Evidence 10 Activity

Activity

IC50
Antifungal
2.8-5 µg/mL

Target

F. culmorum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), an
Evidence 11 Activity

Activity

IC50
Antifungal
1.5 µg/mL

Target

L. maculans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml)
Evidence 12 Activity

Activity

IC50
Antifungal
2 µg/mL

Target

P. digitatum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(
Evidence 13 Activity

Activity

IC50
Antifungal
1 µg/mL

Target

S. tritici

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). It contains 4 S
Evidence 14 Activity

Activity

IC50
Antifungal
4 µg/mL

Target

V. albo-atrum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). It contains 4 S-S bonds. IC50= 50% inhibition of
Evidence 15 Activity

Activity

IC50
Antiparasitic
12 µg/mL

Target

B. cinerea

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
medium A supplemented with 1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5
Evidence 16 Activity

Activity

IC50
Antiparasitic
3 µg/mL

Target

C. sphaerospermum

Source & Reference

DRAMP

Other

1 mM CaCl2 and 50 mM KCl, the peptide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml
Evidence 17 Activity

Activity

IC50
Antiparasitic
2.8-5 µg/mL

Target

F. culmorum

Source & Reference

DRAMP

Other

ide is active against fungi B. cinerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), an
Evidence 18 Activity

Activity

IC50
Antiparasitic
1.5 µg/mL

Target

L. maculans

Source & Reference

DRAMP

Other

inerea (IC50 12 ug/ml), C. sphaerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml)
Evidence 19 Activity

Activity

IC50
Antiparasitic
2 µg/mL

Target

P. digitatum

Source & Reference

DRAMP

Other

aerospermum (IC50 3 ug/ml), F. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(
Evidence 20 Activity

Activity

IC50
Antiparasitic
1 µg/mL

Target

S. tritici

Source & Reference

DRAMP

Other

. culmorum (IC50 2.8-5 ug/ml), L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). It contains 4 S
Evidence 21 Activity

Activity

IC50
Antiparasitic
4 µg/mL

Target

V. albo-atrum

Source & Reference

DRAMP

Other

L. maculans (IC50 1.5 ug/ml), P. digitatum (IC50 2 ug/ml), S. tritici (IC50 1 ug/ml), and V. albo-atrum (IC50 4 ug/ml) (FEBS Lett. 1995 Jul 17 368(2):257-62). It contains 4 S-S bonds. IC50= 50% inhibition of