Back to search

Peptide record

TPDB12220

Antibacterial Anticancer Antifungal Toxicity standard
50 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12220
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 50-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SGRGKTGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYAQRVGAGAPVY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C229H388N84O61
DCEIMW
G
5294.13
12.63
14
0
17
+13
2.60
-0.776
60.60
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
2980
0.56
10
Residue Composition
number
7
A
8
R
1
N
0
D
0
C
0
E
2
Q
9
G
1
H
0
I
3
L
5
K
0
M
1
F
2
P
3
S
2
T
0
W
2
Y
4
V
Amino Acid Distribution
A: 7 R: 8 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 9 H: 1 I: 0 L: 3 K: 5 M: 0 F: 1 P: 2 S: 3 T: 2 W: 0 Y: 2 V: 4
Chemical Descriptors
50 reviewed residue count
C229H388N84O61 sequence-only estimate (linear, free termini)
5294.13 sequence-only estimate (linear, free termini)
12.63 sequence-only estimate (linear, free termini)
+13 sequence-only estimate (linear, free termini)
2.60 sequence-only estimate (linear, free termini)
-0.776 sequence-only estimate (linear, free termini)
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.7 µM

Target

Escherichia coli ML35p

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), and C. albicans 820 (MI
Evidence 2 Activity

Activity

MIC
Antibacterial
1.1 µM

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), and C. albicans 820 (MIC 1 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
1 µM

Target

Candida albicans 820

Source & Reference

dbAMP DRAMP

Other

ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), and C. albicans 820 (MIC 1 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
0.7 µM

Target

Escherichia coli ML35p

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), and C. albicans 820 (MI
Evidence 5 Activity

Activity

MIC
Antifungal
1.1 µM

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), and C. albicans 820 (MIC 1 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
1 µM

Target

Candida albicans 820

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ML35p (MIC 0.7 uM), L. monocytogenes EGD (MIC 1.1 uM), MRSA ATCC 33591 (MIC 0.9 uM), and C. albicans 820 (MIC 1 uM).
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
1-40 µM
Hemolytic Cytotoxic
0% Hemolysis | 1-40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Acipensins - Novel Antimicrobial Peptides from Leukocytes of the Russian Sturgeon Acipenser gueldenstaedtii. | Acta Naturae | 2014