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Peptide record

TPDB12216

Antibacterial Hemolysis Toxicity standard
50 amino acids
Basic Information
3D PDB MODEL
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TPDB12216
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 50-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
RGLRRLGRKIAHGVKKYGPTVLRIIRIAGKKTWWKTWWTKWSQPKKKRKV
Physicochemical Analysis
C285H468N90O58
NDCEMF
K
6083.42
12.81
19
0
18
+18
6.50
-1.002
76.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
28990
476.54
7
Residue Composition
number
2
A
7
R
0
N
0
D
0
C
0
E
1
Q
5
G
1
H
4
I
3
L
11
K
0
M
0
F
2
P
1
S
4
T
5
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 5 H: 1 I: 4 L: 3 K: 11 M: 0 F: 0 P: 2 S: 1 T: 4 W: 5 Y: 1 V: 3
Chemical Descriptors
50
C285H468N90O58
6083.42
12.81
+18
6.50
-1.002
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
3.04 µM
Hemolytic Cytotoxic
50% Hemolysis | 3.04 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 2 Activity

Activity

50% Cell death
Toxicity
4.35 µM
Cytotoxic
50% Cell death | 4.35 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis