TPDB

3D PDB MODEL

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TPDB ID TPDB12205

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP

Sequence_Type

standard

Has_Modification No

Description A 49-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

RYCLSQSHRFKGLCMSSSNCANVCQTENFPGGECKADGATRKCFCKKIC

FASTA

>TPDB12205|Antibacterial;Antifungal|length=49
RYCLSQSHRFKGLCMSSSNCANVCQTENFPGGECKADGATRKCFCKKIC

Formula C223H358N70O69S9

Absent Amino Acids W

Common Amino Acids C

Mass 5412.26

PI 8.52

Basic Residues 9

Acidic Residues 3

Hydrophobic Residues 12

Net Charge +5

Boman Index 9.10

Hydrophobicity -0.451

Aliphatic Index 35.92

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 1990

Absorbance 280nm 36.77

Polar Residues 21

number

3

A

3

R

3

N

1

D

8

C

2

E

2

Q

4

G

1

H

1

I

2

L

5

K

1

M

3

F

1

P

5

S

2

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 3 R: 3 N: 3 D: 1 C: 8 E: 2 Q: 2 G: 4 H: 1 I: 1 L: 2 K: 5 M: 1 F: 3 P: 1 S: 5 T: 2 W: 0 Y: 1 V: 1

Length

49

Formula

C223H358N70O69S9

Mass

5412.26

PI

8.52

Net Charge

+5

Boman Index

9.10

Hydrophobicity

-0.451

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 1.5 µM

Target

Target Organism N. crassa

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against fungi such as N. crassa (IC50 1.5 uM), A. niger (IC50 2.0 uM), and F. solani (IC50 1 uM).

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 2.0 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against fungi such as N. crassa (IC50 1.5 uM), A. niger (IC50 2.0 uM), and F. solani (IC50 1 uM).

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against fungi such as N. crassa (IC50 1.5 uM), A. niger (IC50 2.0 uM), and F. solani (IC50 1 uM).

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 1.5 µM

Target

Target Organism N. crassa

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against fungi such as N. crassa (IC50 1.5 uM), A. niger (IC50 2.0 uM), and F. solani (IC50 1 uM).

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 2.0 µM

Target

Target Organism A. niger

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against fungi such as N. crassa (IC50 1.5 uM), A. niger (IC50 2.0 uM), and F. solani (IC50 1 uM).

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 1 µM

Target

Target Organism F. solani

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against fungi such as N. crassa (IC50 1.5 uM), A. niger (IC50 2.0 uM), and F. solani (IC50 1 uM).