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Peptide record

TPDB12204

Antibacterial Antifungal standard
49 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12204
Antibacterial Antifungal
Anti-infective peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 49-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
FKFGSFIKRMWRSKLAKKLRAKGKELLRDYANRVLSPEEEAAAPAPYPA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C259H413N73O66S1
CQHT
A
5637.64
10.72
12
5
22
+7
2.10
-0.643
70.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
8480
1.50
6
Residue Composition
number
8
A
5
R
1
N
1
D
0
C
4
E
0
Q
2
G
0
H
1
I
5
L
7
K
1
M
3
F
4
P
3
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 8 R: 5 N: 1 D: 1 C: 0 E: 4 Q: 0 G: 2 H: 0 I: 1 L: 5 K: 7 M: 1 F: 3 P: 4 S: 3 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
49 reviewed residue count
C259H413N73O66S1 sequence-only estimate (linear, free termini)
5637.64 sequence-only estimate (linear, free termini)
10.72 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
2.10 sequence-only estimate (linear, free termini)
-0.643 sequence-only estimate (linear, free termini)
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.33 µM

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

Active against Gram+ bacteria S. aureus, 3-7 uM), S. epidermidis (MIC 1.33 uM), B. cereus (MIC 6.3 uM), B. megaterium CGMCC 1.0459 (MIC 0.37 uM), B. subtilis CGMCC 1.24
Evidence 2 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

B. cereus

Source & Reference

NA

Other

Active against Gram+ bacteria S. aureus, 3-7 uM), S. epidermidis (MIC 1.33 uM), B. cereus (MIC 6.3 uM), B. megaterium CGMCC 1.0459 (MIC 0.37 uM), B. subtilis CGMCC 1.2428 (MIC 0.33 uM), M. lut
Evidence 3 Activity

Activity

MIC
Antibacterial
2.76 µM

Target

S. sanguinis

Source & Reference

NA

Other

C 0.37 uM), B. subtilis CGMCC 1.2428 (MIC 0.33 uM), M. luteus CGMCC 1.0290 (MIC 0.33 uM), S. sanguinis (MIC 2.76 uM), S. salivarius MIC 3.8 uM), S. mutans CGMCC 1.2499 (MIC 2.5 uM), S. warneri CGMCC 1.2824
Evidence 4 Activity

Activity

MIC
Antibacterial
8.3 µM

Target

S. griseus NBRC 13350

Source & Reference

NA

Other

s MIC 3.8 uM), S. mutans CGMCC 1.2499 (MIC 2.5 uM), S. warneri CGMCC 1.2824 (MIC 4.3 uM), S. griseus NBRC 13350 (MIC 8.3 uM), S. CGMCC 4.1765 (MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aerugino
Evidence 5 Activity

Activity

MIC
Antibacterial
2.6-5.3 µM

Target

Escherichia coli

Source & Reference

NA

Other

), S. griseus NBRC 13350 (MIC 8.3 uM), S. CGMCC 4.1765 (MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8
Evidence 6 Activity

Activity

MIC
Antibacterial
4-7 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

MIC 8.3 uM), S. CGMCC 4.1765 (MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 1404
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µM

Target

P. solanacearum

Source & Reference

NA

Other

(MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 14041 (MIC 17 uM), S. maltophili
Evidence 8 Activity

Activity

MIC
Antibacterial
3.8 µM

Target

S. enterica ATCC 14028

Source & Reference

NA

Other

acteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 14041 (MIC 17 uM), S. maltophilia CGMCC 1.1788 (MIC 7.1 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
17 µM

Target

S. marcescens ATCC 14041

Source & Reference

NA

Other

aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 14041 (MIC 17 uM), S. maltophilia CGMCC 1.1788 (MIC 7.1 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
1.33 µM

Target

Staphylococcus epidermidis

Source & Reference

Antifungipept

Other

Active against Gram+ bacteria S. aureus, 3-7 uM), S. epidermidis (MIC 1.33 uM), B. cereus (MIC 6.3 uM), B. megaterium CGMCC 1.0459 (MIC 0.37 uM), B. subtilis CGMCC 1.24
Evidence 11 Activity

Activity

MIC
Antifungal
6.3 µM

Target

B. cereus

Source & Reference

Antifungipept

Other

Active against Gram+ bacteria S. aureus, 3-7 uM), S. epidermidis (MIC 1.33 uM), B. cereus (MIC 6.3 uM), B. megaterium CGMCC 1.0459 (MIC 0.37 uM), B. subtilis CGMCC 1.2428 (MIC 0.33 uM), M. lut
Evidence 12 Activity

Activity

MIC
Antifungal
2.76 µM

Target

S. sanguinis

Source & Reference

Antifungipept

Other

C 0.37 uM), B. subtilis CGMCC 1.2428 (MIC 0.33 uM), M. luteus CGMCC 1.0290 (MIC 0.33 uM), S. sanguinis (MIC 2.76 uM), S. salivarius MIC 3.8 uM), S. mutans CGMCC 1.2499 (MIC 2.5 uM), S. warneri CGMCC 1.2824
Evidence 13 Activity

Activity

MIC
Antifungal
8.3 µM

Target

S. griseus NBRC 13350

Source & Reference

Antifungipept

Other

s MIC 3.8 uM), S. mutans CGMCC 1.2499 (MIC 2.5 uM), S. warneri CGMCC 1.2824 (MIC 4.3 uM), S. griseus NBRC 13350 (MIC 8.3 uM), S. CGMCC 4.1765 (MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aerugino
Evidence 14 Activity

Activity

MIC
Antifungal
2.6-5.3 µM

Target

Escherichia coli

Source & Reference

Antifungipept

Other

), S. griseus NBRC 13350 (MIC 8.3 uM), S. CGMCC 4.1765 (MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8
Evidence 15 Activity

Activity

MIC
Antifungal
4-7 µM

Target

Pseudomonas aeruginosa

Source & Reference

Antifungipept

Other

MIC 8.3 uM), S. CGMCC 4.1765 (MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 1404
Evidence 16 Activity

Activity

MIC
Antifungal
8 µM

Target

P. solanacearum

Source & Reference

Antifungipept

Other

(MIC 3 uM), Gram-negative bacteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 14041 (MIC 17 uM), S. maltophili
Evidence 17 Activity

Activity

MIC
Antifungal
3.8 µM

Target

S. enterica ATCC 14028

Source & Reference

Antifungipept

Other

acteria E. coli (MIC 2.6-5.3 uM), P. aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 14041 (MIC 17 uM), S. maltophilia CGMCC 1.1788 (MIC 7.1 uM).
Evidence 18 Activity

Activity

MIC
Antifungal
17 µM

Target

S. marcescens ATCC 14041

Source & Reference

Antifungipept

Other

aeruginosa (MIC 4-7 uM), P. solanacearum (MIC 8 uM), S. enterica ATCC 14028 (MIC 3.8 uM), S. marcescens ATCC 14041 (MIC 17 uM), S. maltophilia CGMCC 1.1788 (MIC 7.1 uM).