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Peptide record

TPDB12196

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

48 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB12196

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept i2APP APD_complete APD_hemolytic Hemolytic2

Sequence_Type

standard

Has_Modification No

Description A 48-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ

FASTA

>TPDB12196|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=48
FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ

Formula C235H409N71O60S1

Absent Amino Acids CHTWY

Common Amino Acids AK

Mass 5221.33

PI 11.72

Basic Residues 12

Acidic Residues 2

Hydrophobic Residues 23

Net Charge +10

Boman Index 9.49

Hydrophobicity -0.204

Aliphatic Index 103.96

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 7

number

Amino Acid Distribution

A: 9 R: 3 N: 2 D: 1 C: 0 E: 1 Q: 3 G: 3 H: 0 I: 2 L: 7 K: 9 M: 1 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 2

Length

Formula

C235H409N71O60S1

Mass

5221.33

11.72

Net Charge

+10

Boman Index

9.49

Hydrophobicity

-0.204

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.2 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aureus (MIC 6.2 uM), E. coli (MIC 1.6 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.6 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus (MIC 6.2 uM), E. coli (MIC 1.6 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.2 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aureus (MIC 6.2 uM), E. coli (MIC 1.6 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.6 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Active against S. aureus (MIC 6.2 uM), E. coli (MIC 1.6 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.2 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against S. aureus (MIC 6.2 uM), E. coli (MIC 1.6 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.6 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus (MIC 6.2 uM), E. coli (MIC 1.6 uM).

Evidence 7 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 100 %

Hemolysis Raw

[Ref.11976325]100% hemolytic activity at 50 µM against sheep red blood cells

Target

RBC Target sheep red blood cells

Source & Reference

Database Source APD_complete APD_hemolytic

Source DRAMP4

Reference

J Biol Chem. 2002 Jun 28 277(26):23627-23637.##Biochim Biophys Acta. 2004 Aug 30 1664(2):182-188.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.

Evidence 8 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.11976325]100% hemolytic activity at 50 µM against sheep red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Biol Chem. 2002 Jun 28 277(26):23627-23637.##Biochim Biophys Acta. 2004 Aug 30 1664(2):182-188.

Evidence 9 Hemolysis

Activity

Activity Measurement 100 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.11976325]100% hemolytic activity at 50 µM against sheep red blood cells

Detail Source Activity Hemolysis

Target

RBC Target sheep red blood cells

Source & Reference

source APD_complete APD_hemolytic

Reference

J Biol Chem. 2002 Jun 28 277(26):23627-23637.##Biochim Biophys Acta. 2004 Aug 30 1664(2):182-188.

Source DRAMP4

Database Source APD_complete APD_hemolytic