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Peptide record

TPDB12193

Antibacterial Antifungal Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB12193
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 48-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
MDSFQKIEKIGEGTYGVVYKAKDKVSGRLVALKKIRLENESEGVPSTA
Physicochemical Analysis
C233H387N63O73S1
CHW
K
5271.07
9.68
9
7
18
+2
17.40
-0.471
85.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
56.53
10
Residue Composition
number
3
A
2
R
1
N
2
D
0
C
5
E
1
Q
5
G
0
H
3
I
3
L
7
K
1
M
1
F
1
P
4
S
2
T
0
W
2
Y
5
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 2 C: 0 E: 5 Q: 1 G: 5 H: 0 I: 3 L: 3 K: 7 M: 1 F: 1 P: 1 S: 4 T: 2 W: 0 Y: 2 V: 5
Chemical Descriptors
48
C233H387N63O73S1
5271.07
9.68
+2
17.40
-0.471
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-10 µM

Target

E. faecium ATCC 19434

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against G+ bacteria S. aureus ATCC 25923, E. faecium ATCC 19434 (MIC 5-10 uM), G- bacteria E. coli O-157 ATCC 43895, P. aeruginosa ATCC 27853 (MIC 5 uM), and fungi C.
Evidence 2 Activity

Activity

MIC
Antibacterial
5 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

us ATCC 25923, E. faecium ATCC 19434 (MIC 5-10 uM), G- bacteria E. coli O-157 ATCC 43895, P. aeruginosa ATCC 27853 (MIC 5 uM), and fungi C. albicans ATCC 90028, C. parapsilosis ATCC 22019, and T. beigelii KCTC 7707
Evidence 3 Activity

Activity

MIC
Antibacterial
10-20 µM

Target

T. beigelii KCTC 7707

Source & Reference

dbAMP DRAMP

Other

ATCC 27853 (MIC 5 uM), and fungi C. albicans ATCC 90028, C. parapsilosis ATCC 22019, and T. beigelii KCTC 7707 (MIC 10-20 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
5-10 µM

Target

E. faecium ATCC 19434

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against G+ bacteria S. aureus ATCC 25923, E. faecium ATCC 19434 (MIC 5-10 uM), G- bacteria E. coli O-157 ATCC 43895, P. aeruginosa ATCC 27853 (MIC 5 uM), and fungi C.
Evidence 5 Activity

Activity

MIC
Antifungal
5 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

us ATCC 25923, E. faecium ATCC 19434 (MIC 5-10 uM), G- bacteria E. coli O-157 ATCC 43895, P. aeruginosa ATCC 27853 (MIC 5 uM), and fungi C. albicans ATCC 90028, C. parapsilosis ATCC 22019, and T. beigelii KCTC 7707
Evidence 6 Activity

Activity

MIC
Antifungal
10-20 µM

Target

T. beigelii KCTC 7707

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ATCC 27853 (MIC 5 uM), and fungi C. albicans ATCC 90028, C. parapsilosis ATCC 22019, and T. beigelii KCTC 7707 (MIC 10-20 uM).
Evidence 7 Activity

Activity

0% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
0% Hemolysis | 80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of a novel antimicrobial peptide, scolopendin 1, derived from centipede Scolopendra subspinipes mutilans and its antifungal mechanism. | Insect Mol Biol | 2014
Evidence 8 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.25209888] 0% hemolysis at 80 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Insect Mol Biol. 2014 Dec 23(6):788-99. doi: 10.1111/imb.12124.