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Peptide record

TPDB12187

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
48 amino acids
Basic Information
3D PDB MODEL
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TPDB12187
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 48-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KESRAKKFQRQHMDSDSSPSSSSTYSNQMMRRRNMTQGRSKPVNTFVH
Physicochemical Analysis
C231H377N81O76S4
CILW
S
5633.27
11.80
12
3
10
+7
17.28
-1.575
14.17
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
26.45
21
Residue Composition
number
1
A
6
R
3
N
2
D
0
C
1
E
4
Q
1
G
2
H
0
I
0
L
4
K
4
M
2
F
2
P
10
S
3
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 6 N: 3 D: 2 C: 0 E: 1 Q: 4 G: 1 H: 2 I: 0 L: 0 K: 4 M: 4 F: 2 P: 2 S: 10 T: 3 W: 0 Y: 1 V: 2
Chemical Descriptors
48
C231H377N81O76S4
5633.27
11.80
+7
17.28
-1.575
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
11.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 11.6 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis