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Peptide record

TPDB12182

Antibacterial Anticancer Antifungal Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12182
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RTCQSQSHRFRGPCLRRSNCANVCRTEGFPGGRCRGFRRRCFCTTHC
Physicochemical Analysis
C220H356N88O61S8
DIKMWY
R
5466.28
11.41
13
1
7
+10
9.65
-0.911
16.60
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
500
9.15
19
Residue Composition
number
1
A
11
R
2
N
0
D
8
C
1
E
2
Q
5
G
2
H
0
I
1
L
0
K
0
M
4
F
2
P
3
S
4
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 11 N: 2 D: 0 C: 8 E: 1 Q: 2 G: 5 H: 2 I: 0 L: 1 K: 0 M: 0 F: 4 P: 2 S: 3 T: 4 W: 0 Y: 0 V: 1
Chemical Descriptors
47
C220H356N88O61S8
5466.28
11.41
+10
9.65
-0.911
Evidence Records 21 records
Evidence 1 Activity

Activity

IC50
Antibacterial
1.5 µM

Target

Staphylococcus aureus ATCC 9144

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Recombinant peptide is active against bacteria S. aureus ATCC 9144 (IC50 1.5 uM), B. subtilis (IC50 0.4 uM), and P. aeruginosa PAO1 (IC50 1.7 uM). Fungi: Also active agai
Evidence 2 Activity

Activity

IC50
Antibacterial
0.4 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

Recombinant peptide is active against bacteria S. aureus ATCC 9144 (IC50 1.5 uM), B. subtilis (IC50 0.4 uM), and P. aeruginosa PAO1 (IC50 1.7 uM). Fungi: Also active against C. albicans in both the
Evidence 3 Activity

Activity

IC50
Antibacterial
1.7 µM

Target

Pseudomonas aeruginosa PAO1

Source & Reference

dbAMP

Other

active against bacteria S. aureus ATCC 9144 (IC50 1.5 uM), B. subtilis (IC50 0.4 uM), and P. aeruginosa PAO1 (IC50 1.7 uM). Fungi: Also active against C. albicans in both the yeast and biofilm form as well as oth
Evidence 4 Activity

Activity

IC50
Antibacterial
3.4 µM

Target

C. auris

Source & Reference

dbAMP

Other

and E. coli in media containing 100 mM NaCl (salt-insensitive). Other fungi inhibited are C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3
Evidence 5 Activity

Activity

IC50
Antibacterial
1.2 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP

Other

taining 100 mM NaCl (salt-insensitive). Other fungi inhibited are C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5
Evidence 6 Activity

Activity

IC50
Antibacterial
0.9 µM

Target

C. krusei

Source & Reference

dbAMP

Other

. Other fungi inhibited are C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1
Evidence 7 Activity

Activity

IC50
Antibacterial
1.3 µM

Target

C. parapsilosis

Source & Reference

dbAMP

Other

re C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1 (IC50 1.0 uM).
Evidence 8 Activity

Activity

IC50
Antibacterial
0.5 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP

Other

labrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1 (IC50 1.0 uM).
Evidence 9 Activity

Activity

IC50
Antibacterial
1.0 µM

Target

F. graminearum PH-1

Source & Reference

dbAMP

Other

rusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1 (IC50 1.0 uM).
Evidence 10 Activity

Activity

IC50
Antifungal
1.5 µM

Target

Staphylococcus aureus ATCC 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Recombinant peptide is active against bacteria S. aureus ATCC 9144 (IC50 1.5 uM), B. subtilis (IC50 0.4 uM), and P. aeruginosa PAO1 (IC50 1.7 uM). Fungi: Also active agai
Evidence 11 Activity

Activity

IC50
Antifungal
0.4 µM

Target

B. subtilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Recombinant peptide is active against bacteria S. aureus ATCC 9144 (IC50 1.5 uM), B. subtilis (IC50 0.4 uM), and P. aeruginosa PAO1 (IC50 1.7 uM). Fungi: Also active against C. albicans in both the
Evidence 12 Activity

Activity

IC50
Antifungal
1.7 µM

Target

Pseudomonas aeruginosa PAO1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against bacteria S. aureus ATCC 9144 (IC50 1.5 uM), B. subtilis (IC50 0.4 uM), and P. aeruginosa PAO1 (IC50 1.7 uM). Fungi: Also active against C. albicans in both the yeast and biofilm form as well as oth
Evidence 13 Activity

Activity

IC50
Antifungal
3.4 µM

Target

C. auris

Source & Reference

dbAMP CAFPdb Antifungipept

Other

and E. coli in media containing 100 mM NaCl (salt-insensitive). Other fungi inhibited are C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3
Evidence 14 Activity

Activity

IC50
Antifungal
1.2 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP CAFPdb Antifungipept

Other

taining 100 mM NaCl (salt-insensitive). Other fungi inhibited are C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5
Evidence 15 Activity

Activity

IC50
Antifungal
0.9 µM

Target

C. krusei

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. Other fungi inhibited are C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1
Evidence 16 Activity

Activity

IC50
Antifungal
1.3 µM

Target

C. parapsilosis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

re C. auris (IC50 3.4 uM), C. glabrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1 (IC50 1.0 uM).
Evidence 17 Activity

Activity

IC50
Antifungal
0.5 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP CAFPdb Antifungipept

Other

labrata ATCC 90030 (IC50 1.2 uM), C. krusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1 (IC50 1.0 uM).
Evidence 18 Activity

Activity

IC50
Antifungal
1.0 µM

Target

F. graminearum PH-1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

rusei (IC50 0.9 uM), C. parapsilosis (IC50 1.3 uM), C. tropicalis ATCC 750 (IC50 0.5 uM), F. graminearum PH-1 (IC50 1.0 uM).
Evidence 19 Activity

Activity

30% Killing
Toxicity
50 µM
Cytotoxic
30% Killing | 50 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32. | Front Microbiol | 2019
Evidence 20 Activity

Activity

1.7% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
1.7% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32. | Front Microbiol | 2019
Evidence 21 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Microbiol. 2019 Apr 12 10:795.