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Peptide record

TPDB12181

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

47 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB12181

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0

Sequence_Type

standard

Has_Modification No

Description A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KTCENLADTFRGPCFATSNCDDHCKNKEHLLSGRCRDDFRCWCTRNC

FASTA

>TPDB12181|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=47
KTCENLADTFRGPCFATSNCDDHCKNKEHLLSGRCRDDFRCWCTRNC

Formula C223H346N74O72S8

Absent Amino Acids QIMYV

Common Amino Acids C

Mass 5472.13

PI 7.51

Basic Residues 10

Acidic Residues 7

Hydrophobic Residues 9

Net Charge +1

Boman Index 12.92

Hydrophobicity -0.923

Aliphatic Index 29.15

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 6000

Absorbance 280nm 109.65

Polar Residues 18

number

Amino Acid Distribution

A: 2 R: 5 N: 4 D: 5 C: 8 E: 2 Q: 0 G: 2 H: 2 I: 0 L: 3 K: 3 M: 0 F: 3 P: 1 S: 2 T: 4 W: 1 Y: 0 V: 0

Length

Formula

C223H346N74O72S8

Mass

5472.13

7.51

Net Charge

Boman Index

12.92

Hydrophobicity

-0.923

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 86 µM

Target

Target Organism M. phlei

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 125 µM

Target

Target Organism B.megaterium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM)

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 101 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM)

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 68 µM

Target

Target Organism P. vulgaris

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.7

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 2.3 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 2.8 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.72 µM

Target

Target Organism M. arachidicola

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 86 µM

Target

Target Organism M. phlei

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 125 µM

Target

Target Organism B.megaterium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM)

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 101 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM)

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 68 µM

Target

Target Organism P. vulgaris

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 2.3 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 2.8 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.72 µM

Target

Target Organism M. arachidicola

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 86 µM

Target

Target Organism M. phlei

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 125 µM

Target

Target Organism B.megaterium

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM)

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 101 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM)

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 68 µM

Target

Target Organism P. vulgaris

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 2.3 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 2.8 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.72 µM

Target

Target Organism M. arachidicola

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 86 µM

Target

Target Organism M. phlei

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 125 µM

Target

Target Organism B.megaterium

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM)

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 101 µM

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

active against bacteria M. phlei (IC50 86 uM), B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM)

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 68 µM

Target

Target Organism P. vulgaris

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 2.3 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

B.megaterium (MIC 125 uM), B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 2.8 µM

Target

Target Organism B. cinerea

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

B.subtilis (IC50 101 uM), and P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 0.72 µM

Target

Target Organism M. arachidicola

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

P. vulgaris (IC50 68 uM), fungi F. oxysporum (IC50 2.3 uM), B. cinerea (IC50 2.8 uM) and M. arachidicola (IC50 0.72 uM). Updated 8/2025