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Peptide record

TPDB12179

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB12179
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RECKTESNTFPGICITKPPCRKACISEKFTDGHCSKILRRCLCTKPC
Physicochemical Analysis
C223H374N68O65S8
QMWYV
C
5304.32
8.75
11
4
9
+6
14.05
-0.472
51.91
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
500
9.43
17
Residue Composition
number
1
A
4
R
1
N
1
D
8
C
3
E
0
Q
2
G
1
H
4
I
2
L
6
K
0
M
2
F
4
P
3
S
5
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 1 C: 8 E: 3 Q: 0 G: 2 H: 1 I: 4 L: 2 K: 6 M: 0 F: 2 P: 4 S: 3 T: 5 W: 0 Y: 0 V: 0
Chemical Descriptors
47
C223H374N68O65S8
5304.32
8.75
+6
14.05
-0.472
Evidence Records 17 records
Evidence 1 Activity

Activity

IC50
Antibacterial
1 µM

Target

p. vasinfectum

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisi
Evidence 2 Activity

Activity

IC50
Antibacterial
0.8 µM

Target

L. maculans

Source & Reference

dbAMP DRAMP

Other

Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cine
Evidence 3 Activity

Activity

IC50
Antibacterial
0.8 µM

Target

A. nidulans

Source & Reference

dbAMP DRAMP

Other

Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus
Evidence 4 Activity

Activity

IC50
Antibacterial
0.75 µM

Target

V. dahliae

Source & Reference

dbAMP DRAMP

Other

rum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus species, activity against
Evidence 5 Activity

Activity

IC50
Antibacterial
0.8 µM

Target

T. bisicola

Source & Reference

dbAMP DRAMP

Other

0 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus species, activity against the yeasts S-cerevisiae, C-
Evidence 6 Activity

Activity

IC50
Antifungal
1 µM

Target

p. vasinfectum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisi
Evidence 7 Activity

Activity

IC50
Antifungal
0.8 µM

Target

L. maculans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cine
Evidence 8 Activity

Activity

IC50
Antifungal
0.8 µM

Target

A. nidulans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus
Evidence 9 Activity

Activity

IC50
Antifungal
0.75 µM

Target

V. dahliae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

rum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus species, activity against
Evidence 10 Activity

Activity

IC50
Antifungal
0.8 µM

Target

T. bisicola

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus species, activity against the yeasts S-cerevisiae, C-
Evidence 11 Activity

Activity

IC50
Antiparasitic
1 µM

Target

p. vasinfectum

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisi
Evidence 12 Activity

Activity

IC50
Antiparasitic
0.8 µM

Target

L. maculans

Source & Reference

DRAMP

Other

Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cine
Evidence 13 Activity

Activity

IC50
Antiparasitic
0.8 µM

Target

A. nidulans

Source & Reference

DRAMP

Other

Active against F. oxysporum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus
Evidence 14 Activity

Activity

IC50
Antiparasitic
0.75 µM

Target

V. dahliae

Source & Reference

DRAMP

Other

rum f. sp. vasinfectum (IC50 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus species, activity against
Evidence 15 Activity

Activity

IC50
Antiparasitic
0.8 µM

Target

T. bisicola

Source & Reference

DRAMP

Other

0 1 uM), L. maculans (IC50 0.8 uM), A. nidulans (IC50 0.8 uM), V. dahliae (IC50 0.75 uM), T. bisicola (IC50 0.8 uM), B. cinerea, A. niger, Cryptococcus species, activity against the yeasts S-cerevisiae, C-
Evidence 16 Activity

Activity

100% Killing
Toxicity
25 µM
Cytotoxic
100% Killing | 25 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32. | Front Microbiol | 2019
Evidence 17 Activity

Activity

1.5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
1.5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32. | Front Microbiol | 2019