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Peptide record

TPDB12175

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB12175
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FRFGSFLKKVWKSKLAKKLRSKGKQLLKDYANKVLNGPEEEAAAPAE
Physicochemical Analysis
C245H397N67O65
CHIMT
K
5321.26
10.56
12
5
19
+7
13.15
-0.736
74.89
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
131.36
7
Residue Composition
number
6
A
2
R
2
N
1
D
0
C
4
E
1
Q
3
G
0
H
0
I
6
L
10
K
0
M
3
F
2
P
3
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 6 R: 2 N: 2 D: 1 C: 0 E: 4 Q: 1 G: 3 H: 0 I: 0 L: 6 K: 10 M: 0 F: 3 P: 2 S: 3 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
47
C245H397N67O65
5321.26
10.56
+7
13.15
-0.736
Evidence Records 41 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.3 µM

Target

Escherichia coli DH5-alpha

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
al activity was demonstrated in 2012 (see the ref). Active against Gram-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enteric
Evidence 2 Activity

Activity

MIC
Antibacterial
3.2 µM

Target

H. influenzae ATCC 31517

Source & Reference

dbAMP DRAMP

Other

2012 (see the ref). Active against Gram-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa
Evidence 3 Activity

Activity

MIC
Antibacterial
2.8 µM

Target

Klebsiella pneumoniae ATCC 13882

Source & Reference

dbAMP DRAMP

Other

-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens
Evidence 4 Activity

Activity

MIC
Antibacterial
2.3 µM

Target

S. enterica ATCC 8090

Source & Reference

dbAMP DRAMP

Other

IC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-posit
Evidence 5 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

Pseudomonas aeruginosa ATCC 9229

Source & Reference

dbAMP DRAMP

Other

(MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
68.2 µM

Target

S. marcescens ATCC 13880

Source & Reference

dbAMP DRAMP

Other

2 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152
Evidence 7 Activity

Activity

MIC
Antibacterial
24.4 µM

Target

B. subtilis ATCC 6051

Source & Reference

dbAMP DRAMP

Other

sa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis
Evidence 8 Activity

Activity

MIC
Antibacterial
5.7 µM

Target

L. monocytogenes ATCC 35152

Source & Reference

dbAMP DRAMP

Other

ens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides AT
Evidence 9 Activity

Activity

MIC
Antibacterial
20.3 µM

Target

M. luteus ATCC 9341

Source & Reference

dbAMP DRAMP

Other

e bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides ATCC 3308 (MIC>70 uM), and S-aureus A
Evidence 10 Activity

Activity

MIC
Antibacterial
57.1 µM

Target

Enterococcus faecalis ATCC 14508

Source & Reference

dbAMP DRAMP

Other

IC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides ATCC 3308 (MIC>70 uM), and S-aureus ATCC 14458 (MIC>70 uM). Also, the pepti
Evidence 11 Activity

Activity

IC50
Antibacterial
2.0 µM

Target

N. crassa FGSC 2489

Source & Reference

dbAMP DRAMP

Other

and S-aureus ATCC 14458 (MIC>70 uM). Also, the peptide is active against fungi, including N. crassa FGSC 2489 (IC50 2.0 uM), B. cinerea ATCC 28387 (3.1 uM) and F. culmorum ATCC 32973 (0.2 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
2.3 µM

Target

Escherichia coli DH5-alpha

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
al activity was demonstrated in 2012 (see the ref). Active against Gram-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enteric
Evidence 13 Activity

Activity

MIC
Antifungal
3.2 µM

Target

H. influenzae ATCC 31517

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2012 (see the ref). Active against Gram-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa
Evidence 14 Activity

Activity

MIC
Antifungal
2.8 µM

Target

Klebsiella pneumoniae ATCC 13882

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens
Evidence 15 Activity

Activity

MIC
Antifungal
2.3 µM

Target

S. enterica ATCC 8090

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-posit
Evidence 16 Activity

Activity

MIC
Antifungal
4.7 µM

Target

Pseudomonas aeruginosa ATCC 9229

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MI
Evidence 17 Activity

Activity

MIC
Antifungal
68.2 µM

Target

S. marcescens ATCC 13880

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152
Evidence 18 Activity

Activity

MIC
Antifungal
24.4 µM

Target

B. subtilis ATCC 6051

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

sa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis
Evidence 19 Activity

Activity

MIC
Antifungal
5.7 µM

Target

L. monocytogenes ATCC 35152

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides AT
Evidence 20 Activity

Activity

MIC
Antifungal
20.3 µM

Target

M. luteus ATCC 9341

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

e bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides ATCC 3308 (MIC>70 uM), and S-aureus A
Evidence 21 Activity

Activity

MIC
Antifungal
57.1 µM

Target

Enterococcus faecalis ATCC 14508

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides ATCC 3308 (MIC>70 uM), and S-aureus ATCC 14458 (MIC>70 uM). Also, the pepti
Evidence 22 Activity

Activity

IC50
Antifungal
2.0 µM

Target

N. crassa FGSC 2489

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

and S-aureus ATCC 14458 (MIC>70 uM). Also, the peptide is active against fungi, including N. crassa FGSC 2489 (IC50 2.0 uM), B. cinerea ATCC 28387 (3.1 uM) and F. culmorum ATCC 32973 (0.2 uM).
Evidence 23 Activity

Activity

MIC
Antiparasitic
2.3 µM

Target

Escherichia coli DH5-alpha

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
al activity was demonstrated in 2012 (see the ref). Active against Gram-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enteric
Evidence 24 Activity

Activity

MIC
Antiparasitic
3.2 µM

Target

H. influenzae ATCC 31517

Source & Reference

DRAMP

Other

2012 (see the ref). Active against Gram-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa
Evidence 25 Activity

Activity

MIC
Antiparasitic
2.8 µM

Target

Klebsiella pneumoniae ATCC 13882

Source & Reference

DRAMP

Other

-negative bacteria E. coli DH5-alpha (MIC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens
Evidence 26 Activity

Activity

MIC
Antiparasitic
2.3 µM

Target

S. enterica ATCC 8090

Source & Reference

DRAMP

Other

IC 2.3 uM), H. influenzae ATCC 31517 (MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-posit
Evidence 27 Activity

Activity

MIC
Antiparasitic
4.7 µM

Target

Pseudomonas aeruginosa ATCC 9229

Source & Reference

DRAMP

Other

(MIC 3.2 uM), K. pneumoniae ATCC 13882 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MI
Evidence 28 Activity

Activity

MIC
Antiparasitic
68.2 µM

Target

S. marcescens ATCC 13880

Source & Reference

DRAMP

Other

2 (MIC 2.8 uM), S. enterica ATCC 8090 (MIC 2.3 uM), P. aeruginosa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152
Evidence 29 Activity

Activity

MIC
Antiparasitic
24.4 µM

Target

B. subtilis ATCC 6051

Source & Reference

DRAMP

Other

sa ATCC 9229 (MIC 4.7 uM), S. marcescens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis
Evidence 30 Activity

Activity

MIC
Antiparasitic
5.7 µM

Target

L. monocytogenes ATCC 35152

Source & Reference

DRAMP

Other

ens ATCC 13880 (MIC 68.2 uM), Gram-positive bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides AT
Evidence 31 Activity

Activity

MIC
Antiparasitic
20.3 µM

Target

M. luteus ATCC 9341

Source & Reference

DRAMP

Other

e bacteria B. subtilis ATCC 6051 (MIC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides ATCC 3308 (MIC>70 uM), and S-aureus A
Evidence 32 Activity

Activity

MIC
Antiparasitic
57.1 µM

Target

Enterococcus faecalis ATCC 14508

Source & Reference

DRAMP

Other

IC 24.4 uM), L. monocytogenes ATCC 35152 (MIC 5.7 uM), M. luteus ATCC 9341 (MIC 20.3 uM), E. faecalis ATCC 14508 (MIC 57.1 uM), N-asteroides ATCC 3308 (MIC>70 uM), and S-aureus ATCC 14458 (MIC>70 uM). Also, the pepti
Evidence 33 Activity

Activity

IC50
Antiparasitic
2.0 µM

Target

N. crassa FGSC 2489

Source & Reference

DRAMP

Other

and S-aureus ATCC 14458 (MIC>70 uM). Also, the peptide is active against fungi, including N. crassa FGSC 2489 (IC50 2.0 uM), B. cinerea ATCC 28387 (3.1 uM) and F. culmorum ATCC 32973 (0.2 uM).
Evidence 34 Activity

Activity

% Hemolysis
Hemolysis
3.5 11.2 22.5 33.9 %
[Ref.22115565]3.5% hemolytic activity at 6 µM, 11.2% hemolytic activity at 10 µM, 22.5% hemolytic activity at 30 µM, 33.9% hemolytic activity at 50 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
IUBMB Life. 2000 Mar 49(3):207-210.##Peptides. 2012 Jan 33(1):44-51.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 35 Activity

Activity

0% Hemolysis
Toxicity
3 µM
Hemolytic Cytotoxic
0% Hemolysis | 3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. | Peptides | 2012
Evidence 36 Activity

Activity

4% Hemolysis
Toxicity
6 µM
Hemolytic Cytotoxic
4% Hemolysis | 6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. | Peptides | 2012
Evidence 37 Activity

Activity

11% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
11% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. | Peptides | 2012
Evidence 38 Activity

Activity

23% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
23% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. | Peptides | 2012
Evidence 39 Activity

Activity

40% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
40% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. | Peptides | 2012
Evidence 40 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.22115565]3.5% hemolytic activity at 6 µM, 11.2% hemolytic activity at 10 µM, 22.5% hemolytic activity at 30 µM, 33.9% hemolytic activity at 50 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
IUBMB Life. 2000 Mar 49(3):207-210.##Peptides. 2012 Jan 33(1):44-51.
Evidence 41 Hemolysis

Activity

3.5 11.2 22.5 33.9 %
% Hemolysis
[Ref.22115565]3.5% hemolytic activity at 6 µM, 11.2% hemolytic activity at 10 µM, 22.5% hemolytic activity at 30 µM, 33.9% hemolytic activity at 50 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
IUBMB Life. 2000 Mar 49(3):207-210.##Peptides. 2012 Jan 33(1):44-51.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.