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Peptide record

TPDB12174

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12174
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
DFGCGQGMIFMCQRRCMRLYPGSTGFCRGFRCMCDTHIPLRPPFMVG
Physicochemical Analysis
C231H357N69O58S11
ANEKW
G
5381.46
8.60
7
2
16
+4
0.87
0.051
39.36
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1865
34.66
12
Residue Composition
number
0
A
6
R
0
N
2
D
6
C
0
E
2
Q
7
G
1
H
2
I
2
L
0
K
5
M
5
F
4
P
1
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 2 C: 6 E: 0 Q: 2 G: 7 H: 1 I: 2 L: 2 K: 0 M: 5 F: 5 P: 4 S: 1 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
47
C231H357N69O58S11
5381.46
8.60
+4
0.87
0.051
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.2-6.4 µg/mL

Target

Escherichia coli ATCC25922 or 23A or 27A

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H
Evidence 2 Activity

Activity

MIC
Antibacterial
0.8-1.6 µg/mL

Target

Staphylococcus aureus ATCC2592 or 6A or 15A

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans A
Evidence 3 Activity

Activity

MIC
Antibacterial
3.2 µg/mL

Target

Pseudomonas aeruginosa 3A

Source & Reference

dbAMP DRAMP

Other

2 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
6.4 µg/mL

Target

H. pylori NCTC11637

Source & Reference

dbAMP DRAMP

Other

), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
25.6 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
3.2-6.4 µg/mL

Target

Escherichia coli ATCC25922 or 23A or 27A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H
Evidence 7 Activity

Activity

MIC
Antifungal
0.8-1.6 µg/mL

Target

Staphylococcus aureus ATCC2592 or 6A or 15A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans A
Evidence 8 Activity

Activity

MIC
Antifungal
3.2 µg/mL

Target

Pseudomonas aeruginosa 3A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
6.4 µg/mL

Target

H. pylori NCTC11637

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
25.6 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 11 Activity

Activity

MIC
Antiparasitic
3.2-6.4 µg/mL

Target

Escherichia coli ATCC25922 or 23A or 27A

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H
Evidence 12 Activity

Activity

MIC
Antiparasitic
0.8-1.6 µg/mL

Target

Staphylococcus aureus ATCC2592 or 6A or 15A

Source & Reference

DRAMP

Other

Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans A
Evidence 13 Activity

Activity

MIC
Antiparasitic
3.2 µg/mL

Target

Pseudomonas aeruginosa 3A

Source & Reference

DRAMP

Other

2 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 14 Activity

Activity

MIC
Antiparasitic
6.4 µg/mL

Target

H. pylori NCTC11637

Source & Reference

DRAMP

Other

), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 15 Activity

Activity

MIC
Antiparasitic
25.6 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 16 Activity

Activity

MIC
Antiviral
3.2-6.4 µg/mL

Target

Escherichia coli ATCC25922 or 23A or 27A

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H
Evidence 17 Activity

Activity

MIC
Antiviral
0.8-1.6 µg/mL

Target

Staphylococcus aureus ATCC2592 or 6A or 15A

Source & Reference

DRAMP

Other

Active against E. coli ATCC25922 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans A
Evidence 18 Activity

Activity

MIC
Antiviral
3.2 µg/mL

Target

Pseudomonas aeruginosa 3A

Source & Reference

DRAMP

Other

2 or 23A or 27A (MIC 3.2-6.4 ug/ml), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 19 Activity

Activity

MIC
Antiviral
6.4 µg/mL

Target

H. pylori NCTC11637

Source & Reference

DRAMP

Other

), S. aureus ATCC2592 or 6A or 15A (MIC 0.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 20 Activity

Activity

MIC
Antiviral
25.6 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

.8-1.6 ug/ml), P. aeruginosa 3A (MIC 3.2 ug/ml), H. pylori NCTC11637 (MIC 6.4 ug/ml), and C. albicans ATCC2002 (MIC 25.6 ug/ml).
Evidence 21 Activity

Activity

1% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
A novel defensin-like peptide from salivary glands of the hard tick, Haemaphysalis longicornis. | Protein Sci | 2010