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Peptide record

TPDB12171

Antibacterial Antifungal Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB12171
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RISFKKGKGSWIKNGLIKGIKGLGKEISLDVIRTGIDIAGCKIKGEC
Physicochemical Analysis
C225H388N64O61S2
QHMPY
GIK
5030.07
10.43
11
4
16
+7
10.04
-0.074
107.87
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5625
111.83
7
Residue Composition
number
1
A
2
R
1
N
2
D
2
C
2
E
0
Q
9
G
0
H
9
I
3
L
9
K
0
M
1
F
0
P
3
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 2 C: 2 E: 2 Q: 0 G: 9 H: 0 I: 9 L: 3 K: 9 M: 0 F: 1 P: 0 S: 3 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
47
C225H388N64O61S2
5030.07
10.43
+7
10.04
-0.074
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>480 µM
Hemolytic Cytotoxic
50% Hemolysis | >480 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii. | Biochimie | 2012
Evidence 2 Activity

Activity

LD50
Toxicity
480 µM
Hemolytic
Hemolytic_activity: [Ref.22426384] LD50>480 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2012 Jun 94(6):1317-1326.