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Peptide record

TPDB12166

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB12166
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
QDNSRYTHFLTQHYDAKPQGRDDRYSESIMRRRGLTSPSKDINTFIH
Physicochemical Analysis
C242H374N78O77S1
CWV
R
5640.17
9.81
11
6
12
+2
15.07
-1.430
43.62
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
4470
79.25
17
Residue Composition
number
1
A
6
R
2
N
5
D
0
C
1
E
3
Q
2
G
3
H
3
I
2
L
2
K
1
M
2
F
2
P
5
S
4
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 6 N: 2 D: 5 C: 0 E: 1 Q: 3 G: 2 H: 3 I: 3 L: 2 K: 2 M: 1 F: 2 P: 2 S: 5 T: 4 W: 0 Y: 3 V: 0
Chemical Descriptors
47
C242H374N78O77S1
5640.17
9.81
+2
15.07
-1.430
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis