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Peptide record

TPDB12162

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB12162
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
QDGMYQRFLRQHVHPEETGGSDRYSNLMMQRRKMTLYHSKRFNTFIH
Physicochemical Analysis
C253H389N81O71S4
ACW
R
5829.61
10.46
12
4
15
+4
12.58
-1.228
39.36
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
4470
76.68
15
Residue Composition
number
0
A
6
R
2
N
2
D
0
C
2
E
4
Q
3
G
4
H
1
I
3
L
2
K
4
M
3
F
1
P
3
S
3
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 2 D: 2 C: 0 E: 2 Q: 4 G: 3 H: 4 I: 1 L: 3 K: 2 M: 4 F: 3 P: 1 S: 3 T: 3 W: 0 Y: 3 V: 1
Chemical Descriptors
47
C253H389N81O71S4
5829.61
10.46
+4
12.58
-1.228
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
15.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 15.2 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Ribonucleases as a host-defence family: evidence of evolutionarily conserved antimicrobial activity at the N-terminus. | Biochem J | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Sep 14 20(18):4558.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis