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Peptide record

TPDB12151

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12151
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
PDPGQPWQVKAGRPPCYSIPCRKHDECRVGSCSRCNNGLWGDRTCR
Physicochemical Analysis
C216H338N74O64S6
MF
RCP
5187.88
8.59
9
4
8
+4
11.81
-1.093
31.74
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
12865
247.98
15
Residue Composition
number
1
A
6
R
2
N
3
D
6
C
1
E
2
Q
5
G
1
H
1
I
1
L
2
K
0
M
0
F
6
P
3
S
1
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 6 N: 2 D: 3 C: 6 E: 1 Q: 2 G: 5 H: 1 I: 1 L: 1 K: 2 M: 0 F: 0 P: 6 S: 3 T: 1 W: 2 Y: 1 V: 2
Chemical Descriptors
46
C216H338N74O64S6
5187.88
8.59
+4
11.81
-1.093
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.8 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml
Evidence 2 Activity

Activity

MIC
Antibacterial
12.3 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5
Evidence 3 Activity

Activity

MIC
Antibacterial
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswaji
Evidence 4 Activity

Activity

MIC
Antibacterial
3.2 µg/mL

Target

Escherichia coli Edl 933

Source & Reference

dbAMP DRAMP

Other

inst B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswajit Mishra. Updated 2/2020 6/2023
Evidence 5 Activity

Activity

MIC
Antifungal
5.8 µg/mL

Target

B. cereus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml
Evidence 6 Activity

Activity

MIC
Antifungal
12.3 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5
Evidence 7 Activity

Activity

MIC
Antifungal
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswaji
Evidence 8 Activity

Activity

MIC
Antifungal
3.2 µg/mL

Target

Escherichia coli Edl 933

Source & Reference

dbAMP DRAMP Antifungipept

Other

inst B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswajit Mishra. Updated 2/2020 6/2023
Evidence 9 Activity

Activity

MIC
Antiparasitic
5.8 µg/mL

Target

B. cereus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml
Evidence 10 Activity

Activity

MIC
Antiparasitic
12.3 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5
Evidence 11 Activity

Activity

MIC
Antiparasitic
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswaji
Evidence 12 Activity

Activity

MIC
Antiparasitic
3.2 µg/mL

Target

Escherichia coli Edl 933

Source & Reference

DRAMP

Other

inst B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswajit Mishra. Updated 2/2020 6/2023
Evidence 13 Activity

Activity

MIC
Antiviral
5.8 µg/mL

Target

B. cereus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml
Evidence 14 Activity

Activity

MIC
Antiviral
12.3 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5
Evidence 15 Activity

Activity

MIC
Antiviral
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswaji
Evidence 16 Activity

Activity

MIC
Antiviral
3.2 µg/mL

Target

Escherichia coli Edl 933

Source & Reference

DRAMP

Other

inst B. cereus (MIC 5.8 ug/ml), B. subtilis (MIC 12.3 ug/ml), S. aureus (MIC 10.4 ug/ml), E. coli Edl 933 (MIC 3.2 ug/ml), and E. coli MG/655 (MIC 6.5 ug/ml). Provided by Biswajit Mishra. Updated 2/2020 6/2023
Evidence 17 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of a novel salivary antimicrobial peptide from the tick, Ixodes scapularis. | Biochem Biophys Res Commun | 2009
Evidence 18 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.19852941]Insignificant hemolytic activity even up to 150 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Exp Biol. 2002 Sep 205(Pt 18):2843-2864.##Biochem Biophys Res Commun. 2009 Dec 18 390(3):511-515.