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Peptide record

TPDB12148

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12148
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC
Physicochemical Analysis
C219H366N60O58S3
QPWY
G
4863.86
10.11
10
4
18
+5
9.83
0.191
97.39
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
2.57
5
Residue Composition
number
2
A
1
R
1
N
2
D
2
C
2
E
0
Q
9
G
1
H
6
I
2
L
8
K
1
M
3
F
0
P
1
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 2 C: 2 E: 2 Q: 0 G: 9 H: 1 I: 6 L: 2 K: 8 M: 1 F: 3 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
46
C219H366N60O58S3
4863.86
10.11
+5
9.83
0.191
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 12.5 uM), and C-albicans ATCC 90028 (MIC > 50 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 12.5 uM), and C-albicans ATCC 90028 (MIC > 50 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 12.5 uM), and C-albicans ATCC 90028 (MIC > 50 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 12.5 uM), and C-albicans ATCC 90028 (MIC > 50 uM).
Evidence 5 Activity

Activity

MIC
Antiparasitic
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 12.5 uM), and C-albicans ATCC 90028 (MIC > 50 uM).
Evidence 6 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus aureus NCTC 8325

Source & Reference

DRAMP

Other

Active against E. coli ATCC 25922 (MIC 6 uM), S. aureus NCTC 8325 (MIC 12.5 uM), and C-albicans ATCC 90028 (MIC > 50 uM).
Evidence 7 Activity

Activity

LC50
Hemolysis
210 µM
[Ref.16621155] LC50=210 µM against human erythrocytes.

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides 2006 27: 2111-2117.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
210 µM
Hemolytic Cytotoxic
50% Hemolysis | 210 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 9 Activity

Activity

LC50
Toxicity
210 µM
Hemolytic
Hemolytic_activity: [Ref.16621155] LC50=210 µM against human erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 2006 27: 2111-2117.
Evidence 10 Hemolysis

Activity

210 µM
LC50
[Ref.16621155] LC50=210 µM against human erythrocytes.
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides 2006 27: 2111-2117.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.