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Peptide record

TPDB12143

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12143
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC
Physicochemical Analysis
C226H381N59O61S3
QHSWY
K
4997.05
10.05
10
5
17
+5
11.84
0.030
95.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
2.50
6
Residue Composition
number
1
A
1
R
1
N
3
D
2
C
2
E
0
Q
7
G
0
H
6
I
2
L
9
K
1
M
3
F
1
P
0
S
3
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 3 C: 2 E: 2 Q: 0 G: 7 H: 0 I: 6 L: 2 K: 9 M: 1 F: 3 P: 1 S: 0 T: 3 W: 0 Y: 0 V: 4
Chemical Descriptors
46
C226H381N59O61S3
4997.05
10.05
+5
11.84
0.030
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
3 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

C.albicans

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 10 Activity

Activity

MIC
Antiviral
3 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 11 Activity

Activity

MIC
Antiviral
60 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 12 Activity

Activity

MIC
Antiviral
>200 µM

Target

C.albicans

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against E. coli (MIC 3 uM) and S. aureus (MIC 60 uM), but not C.albicans (MIC >200 uM).
Evidence 13 Activity

Activity

HC50
Hemolysis
120 µM
[Ref:12429503] HC50=120 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
120 µM
Hemolytic Cytotoxic
50% Hemolysis | 120 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata. | Biochim Biophys Acta | 2002
Evidence 15 Activity

Activity

HC50
Toxicity
120 µM
Hemolytic
Hemolytic_activity: [Ref:12429503] HC50=120 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
Evidence 16 Hemolysis

Activity

120 µM
HC50
[Ref:12429503] HC50=120 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.