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Peptide record

TPDB12138

Antibacterial Antifungal Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12138
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AATKPKKAGAEAAPKKPAKKQTKKKPAKKAGGKKKPKRAGAKKAKK
Physicochemical Analysis
C213H390N70O52
NDCHILMFSWYV
K
4763.88
11.71
21
1
12
+20
23.74
-1.715
26.09
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
12
A
1
R
0
N
0
D
0
C
1
E
1
Q
4
G
0
H
0
I
0
L
20
K
0
M
0
F
5
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 12 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 4 H: 0 I: 0 L: 0 K: 20 M: 0 F: 0 P: 5 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
46
C213H390N70O52
4763.88
11.71
+20
23.74
-1.715
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
This Ala (>25%) and Lys-rich peptide (43%) is active against B. subtilis KCTC1021, B. subtilis RM125, S. aureus RM4220, E. coli D31, E. coli KCTC1116, P. aeruginosa KCTC2004, S. enterica KCTC2514, S. flexneri KCTC2517 (MEC 0.2-3.9 uM), fish pathogen A. hydrophila KCTC2358, and V. parahaemolyticus KCCM41664 (MEC 0.4-0.7 uM). Not active against C.albicans (MEC > 250 uM). MEC (minimal effective concentration) to inhibit the bacterial growth in radial diffusion asssay by diluting the peptide every 2 fold as in the microdilution assay. No hemolysis at 100 ug/mL. May target an intracellular target. Updated 6/2019 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
This Ala (>25%) and Lys-rich peptide (43%) is active against B. subtilis KCTC1021, B. subtilis RM125, S. aureus RM4220, E. coli D31, E. coli KCTC1116, P. aeruginosa KCTC2004, S. enterica KCTC2514, S. flexneri KCTC2517 (MEC 0.2-3.9 uM), fish pathogen A. hydrophila KCTC2358, and V. parahaemolyticus KCCM41664 (MEC 0.4-0.7 uM). Not active against C.albicans (MEC > 250 uM). MEC (minimal effective concentration) to inhibit the bacterial growth in radial diffusion asssay by diluting the peptide every 2 fold as in the microdilution assay. No hemolysis at 100 ug/mL. May target an intracellular target. Updated 6/2019 7/2021
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide, hdMolluscidin, purified from the gill of the abalone, Haliotis discus. | Fish Shellfish Immunol | 2016