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Peptide record

TPDB12129

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12129
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
RTCMIKKEGWGKCLIDTTCAHSCKNRGYIGGNCKGMTRTCYCLVNC
Physicochemical Analysis
C211H348N66O62S10
QFP
C
5122.09
8.73
9
2
12
+6
5.48
-0.283
50.87
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8980
175.32
19
Residue Composition
number
1
A
3
R
3
N
1
D
8
C
1
E
0
Q
6
G
1
H
3
I
2
L
5
K
2
M
0
F
0
P
1
S
5
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 3 D: 1 C: 8 E: 1 Q: 0 G: 6 H: 1 I: 3 L: 2 K: 5 M: 2 F: 0 P: 0 S: 1 T: 5 W: 1 Y: 2 V: 1
Chemical Descriptors
46
C211H348N66O62S10
5122.09
8.73
+6
5.48
-0.283
Evidence Records 30 records
Evidence 1 Activity

Activity

IC50
Antibacterial
36.6 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
recombinant peptide inhibited Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typ
Evidence 2 Activity

Activity

IC50
Antibacterial
>500 µg/mL

Target

B.cereus

Source & Reference

dbAMP DRAMP

Other

recombinant peptide inhibited Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml),
Evidence 3 Activity

Activity

IC50
Antibacterial
40.8 µg/mL

Target

v. vesicatoria

Source & Reference

dbAMP DRAMP

Other

Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora
Evidence 4 Activity

Activity

IC50
Antibacterial
143.4 µg/mL

Target

S.typhimurium

Source & Reference

dbAMP DRAMP

Other

g/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC
Evidence 5 Activity

Activity

IC50
Antibacterial
>500 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enterit
Evidence 6 Activity

Activity

IC50
Antibacterial
1000 µg/mL

Target

v. carotovora

Source & Reference

dbAMP DRAMP

Other

0 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae
Evidence 7 Activity

Activity

IC50
Antibacterial
>1000 µg/mL

Target

P.vulgaris

Source & Reference

dbAMP DRAMP

Other

0 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. o
Evidence 8 Activity

Activity

IC50
Antibacterial
>1000 µg/mL

Target

S.enteritidis

Source & Reference

dbAMP DRAMP

Other

00 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P.
Evidence 9 Activity

Activity

IC50
Antibacterial
>1000 µg/mL

Target

v. syringae

Source & Reference

dbAMP DRAMP

Other

1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P. oryza, R. solani, and T.rubrum ()IC50 >500 u
Evidence 10 Activity

Activity

IC50
Antibacterial
30-53.2 µg/mL

Target

F. oxysporum

Source & Reference

dbAMP DRAMP

Other

/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P. oryza, R. solani, and T.rubrum ()IC50 >500 ug/ml) ( Chen et al., 2005 ). It is also i
Evidence 11 Activity

Activity

IC50
Antifungal
36.6 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
recombinant peptide inhibited Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typ
Evidence 12 Activity

Activity

IC50
Antifungal
>500 µg/mL

Target

B.cereus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

recombinant peptide inhibited Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml),
Evidence 13 Activity

Activity

IC50
Antifungal
40.8 µg/mL

Target

v. vesicatoria

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora
Evidence 14 Activity

Activity

IC50
Antifungal
143.4 µg/mL

Target

S.typhimurium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

g/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC
Evidence 15 Activity

Activity

IC50
Antifungal
>500 µg/mL

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enterit
Evidence 16 Activity

Activity

IC50
Antifungal
1000 µg/mL

Target

v. carotovora

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae
Evidence 17 Activity

Activity

IC50
Antifungal
>1000 µg/mL

Target

P.vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. o
Evidence 18 Activity

Activity

IC50
Antifungal
>1000 µg/mL

Target

S.enteritidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

00 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P.
Evidence 19 Activity

Activity

IC50
Antifungal
>1000 µg/mL

Target

v. syringae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P. oryza, R. solani, and T.rubrum ()IC50 >500 u
Evidence 20 Activity

Activity

IC50
Antifungal
30-53.2 µg/mL

Target

F. oxysporum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P. oryza, R. solani, and T.rubrum ()IC50 >500 ug/ml) ( Chen et al., 2005 ). It is also i
Evidence 21 Activity

Activity

IC50
Antiparasitic
36.6 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
recombinant peptide inhibited Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typ
Evidence 22 Activity

Activity

IC50
Antiparasitic
>500 µg/mL

Target

B.cereus

Source & Reference

DRAMP

Other

recombinant peptide inhibited Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml),
Evidence 23 Activity

Activity

IC50
Antiparasitic
40.8 µg/mL

Target

v. vesicatoria

Source & Reference

DRAMP

Other

Gram+ S. epidermidis (IC50 36.6 ug/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora
Evidence 24 Activity

Activity

IC50
Antiparasitic
143.4 µg/mL

Target

S.typhimurium

Source & Reference

DRAMP

Other

g/ml), B.cereus (IC50 >500 ug/ml), Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC
Evidence 25 Activity

Activity

IC50
Antiparasitic
>500 µg/mL

Target

E.coli

Source & Reference

DRAMP

Other

Gram- X. campestris pv. vesicatoria (IC50 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enterit
Evidence 26 Activity

Activity

IC50
Antiparasitic
1000 µg/mL

Target

v. carotovora

Source & Reference

DRAMP

Other

0 40.8 ug/ml), S.typhimurium (IC50 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae
Evidence 27 Activity

Activity

IC50
Antiparasitic
>1000 µg/mL

Target

P.vulgaris

Source & Reference

DRAMP

Other

0 143.4 ug/ml), E.coli (IC50 >500 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. o
Evidence 28 Activity

Activity

IC50
Antiparasitic
>1000 µg/mL

Target

S.enteritidis

Source & Reference

DRAMP

Other

00 ug/ml), E. carotovora pv. carotovora (IC50 1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P.
Evidence 29 Activity

Activity

IC50
Antiparasitic
>1000 µg/mL

Target

v. syringae

Source & Reference

DRAMP

Other

1000 ug/ml), P.vulgaris (IC50 >1000 ug/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P. oryza, R. solani, and T.rubrum ()IC50 >500 u
Evidence 30 Activity

Activity

IC50
Antiparasitic
30-53.2 µg/mL

Target

F. oxysporum

Source & Reference

DRAMP

Other

/ml), S.enteritidis (IC50 >1000 ug/ml), P.syringae pv. syringae (IC50 >1000 ug/ml), fungi F. oxysporum (IC50 30-53.2 ug/ml), P. oryza, R. solani, and T.rubrum ()IC50 >500 ug/ml) ( Chen et al., 2005 ). It is also i