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Peptide record

TPDB12121

Antibacterial Antifungal Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12121
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb
standard
No
A 46-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
FFFHIIKGLFHAGRMIHGLVNRRRHRHGMEELDLDQRAFEREKAFA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C252H387N81O61S2
CPSTWY
R
5591.47
11.17
14
6
20
+3
2.69
-0.526
74.35
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
4
A
7
R
1
N
2
D
0
C
4
E
1
Q
4
G
5
H
3
I
4
L
2
K
2
M
6
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 7 N: 1 D: 2 C: 0 E: 4 Q: 1 G: 4 H: 5 I: 3 L: 4 K: 2 M: 2 F: 6 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
46 reviewed residue count
C252H387N81O61S2 sequence-only estimate (linear, free termini)
5591.47 sequence-only estimate (linear, free termini)
11.17 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
2.69 sequence-only estimate (linear, free termini)
-0.526 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

27% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
27% Hemolysis | 20 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016
Evidence 2 Activity

Activity

47% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
47% Hemolysis | 20 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016