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Peptide record

TPDB12120

Antibacterial Antifungal Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12120
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ALGDFFRKSKEKIGKEFKRIVQRIKDFLRNLAKRHHGYKRKFHLEY
Physicochemical Analysis
C265H421N81O62
CMPTW
K
5733.76
11.04
18
5
17
+10
15.36
-1.093
70.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
51.97
5
Residue Composition
number
2
A
6
R
1
N
2
D
0
C
3
E
1
Q
3
G
3
H
3
I
4
L
9
K
0
M
5
F
0
P
1
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 2 C: 0 E: 3 Q: 1 G: 3 H: 3 I: 3 L: 4 K: 9 M: 0 F: 5 P: 0 S: 1 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
46
C265H421N81O62
5733.76
11.04
+10
15.36
-1.093
Evidence Records 3 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
3% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. | Gene | 2018
Evidence 2 Activity

Activity

10.4±2.2% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
10.4±2.2% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Expression in Escherichia coli of novel recombinant hybrid antimicrobial peptide AL32-P113 with enhanced antimicrobial activity in vitro. | Gene | 2018
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.29859288] Hemolysis 10.4 ± 2.2% at 500 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Gene. 2018 May 30. pii: S0378-1119(18)30617-6.