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Peptide record

TPDB12118

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB12118
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIFSKINKKKAKTGLFNIIKTVGKEAGMDVIRAGIDTISCKIKGEC
Physicochemical Analysis
C218H376N60O62S3
QHPWY
K
4925.93
10.25
10
4
17
+6
11.42
-0.013
95.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
2.54
9
Residue Composition
number
3
A
1
R
2
N
2
D
2
C
2
E
0
Q
6
G
0
H
8
I
1
L
9
K
1
M
2
F
0
P
2
S
3
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 2 D: 2 C: 2 E: 2 Q: 0 G: 6 H: 0 I: 8 L: 1 K: 9 M: 1 F: 2 P: 0 S: 2 T: 3 W: 0 Y: 0 V: 2
Chemical Descriptors
46
C218H376N60O62S3
4925.93
10.25
+6
11.42
-0.013
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
13 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
13 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
>200 µM

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 8 Activity

Activity

MIC
Antiparasitic
13 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

C.albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 10 Activity

Activity

MIC
Antiviral
2 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 11 Activity

Activity

MIC
Antiviral
13 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 12 Activity

Activity

MIC
Antiviral
>200 µM

Target

C.albicans

Source & Reference

DRAMP

Other

Active against E. coli (MIC 2 uM) and S. aureus (MIC 13 uM) but not C.albicans (MIC>200 uM).
Evidence 13 Activity

Activity

HC50
Hemolysis
180 µM
[Ref:12429503] HC50=180 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
180 µM
Hemolytic Cytotoxic
50% Hemolysis | 180 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata. | Biochim Biophys Acta | 2002
Evidence 15 Activity

Activity

HC50
Toxicity
180 µM
Hemolytic
Hemolytic_activity: [Ref:12429503] HC50=180 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
Evidence 16 Hemolysis

Activity

180 µM
HC50
[Ref:12429503] HC50=180 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochim Biophys Acta. 2002 Nov 19 1601(1):55-63.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.